Doc 0000173491

"'::-:-"-=::.:::-..~·.:-.:_;:':"':':.:.~~;.. .. ·.:..:.;·;~::-..:··.:-~::::.-·.:"···..-.. ... :-;:.~.:.;~.:::~~--- · :-~~-s£;·--~·--:-~-4- --~;;.~:·.:.L-:.:-.: .;..:.:. ...... ~-v ~fr'~---·,;;.=:: .. ._.-: ....... .-..-.... ... ···~7- __ .. --·--· ----------- ;""· ·-.~ GIVE@ ATTEMPTS TO BLOCK LSD REACTION WITri SOL SIMULTANEOUSlY ''II I TH LSD .. These experiments were c~rrlcd out because the close chemical stmllarlty of BOL and LSD suggest~d that BOL might block the LSD r~actlon by competing. with LSD for receptor sltes. Subjects used were IS nontolerant former morphine addicts, all Negro males who were rn good physical con dition who presented no evidence of major psychoses • • Most of these patients had had considerable experience with LSD. They received, ln randomized order, the following drug combinaHons: BOl placebo plus LSD placebo; BOL plus LSD; and BOl placebo plus LSD. The combtnatton of BOL plus LSD placebo was not studlcd because of the shortage of BOL, and also because the results should be tdenttcal wirh those described In the repor~ dealing wl~h the acute effects of BOL. The dosage of SOL was ~-4 mg./70 ~C• of bodyweTght and was given with the LSD. Nine pattenti receivid the .. hlgher dose. The dose of.LSD was 0.5-t.S mcgm./kg. Smaller doses were used"in rhe ftrst pathnts tested, because of the ;>ossibtl Hy that the drugs might synergtze. ~ --···- --~- ·---------- -· _,. .. --- ·- ·----. . ------------·-----------·-·· --- .. ·- --------~ '.. . - Included for M~thods. M~asurem~nts thr~shold kneejer~s, pupillary diameter, systolic blood pressur~, th~.Abramson- . , Jarvtk questionnaire, and grading Of mental effects usfng seale previously The results are shown ln th~ d~scrtbed. the a copy of which was sent with my letter of tabl~, 8 March 1957. It is obvious that th~re was no slgntffcant blocking of LSD reaction and no of tt. th~ aec~ntuatton Co.nclusfon. Admtnlitratron of BOL stmultaneous.Jy with LSD do~s not block or accentuate the LSD reaction. There ts no reason to believe that giving LSD ~l aft~r any different results, since Gtnzel and Mayer would,gtv~ Gross have reported that Intravenous admfnfstratton of BOL does not reverse the LSD reaction. These results suggest that attenuation of the LSD reaction observed after th~ two days pre-treatment with LSD is due to the development Of cross tolerance. --- -------------- - ------- --------- ---------- - --- -------- - -· - .-··--..............__. ..: .. .: :..-; ............,.:_·~-~ -.. ·----·--·~·.:..,N".,to;.·z.·. ..... ~.~. :. ..;.,~; ·..:. :,-~;c;.- ·. . : ·-. .. ·:, •.;,..' • The image displays a digitally created graphic that serves as a title page or introductory screen for a collection of declassified documents. On the left, a stylized, metallic vault door with complex locking mechanisms is depicted, bathed in a cool blue light. The words "THE BLACK VAULT" are prominently displayed in large, stylized white lettering against a dark, gradient background with a blueish, textured glow. To the right of the vault imagery, white text on a black background provides information about the document's origin from "The Black Vault" online database, specifically mentioning the "MKULTRA/Mind Control Collection" and its declassification by the CIA. A yellow hyperlink to "http://mkultra.theblackvault.com" is also visible. There are no photographs, handwritten notes, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures in this graphic. observed after th~ two days pre-treatment with LSD is due to the development Of cross tolerance. --- -------------- - ------- --------- ---------- - --- -------- - -· - .-··--..............__. ..: .. .: :..-; ............,.:_·~-~ -.. ·----·--·~·.:..,N".,to;.·z.·. ..... ~.~. :. ..;.,~; ·..:. :,-~;c;.- ·. . : ·-. .. ·:, •.;,..' • .;: .. w·., -.J i I l l DlscussTon. Because of the tnconelustveness of j l the experiment tt wtll have to be re~ted. Fortunately ~e have succeeded tn obtaining an addttlon~l supply of ·eoL and wlll repeat the experiment using a larger number of all of whom will be tested with LSD prior subj~cts, to of the formal experiment In order to tn~ttatton eliminate nonrcactors or to establish a dosage which will create a stgntftcant degree of reaction_. We Intend ·to give SOL for three days prtor to LSD, two • days prior to LSD, and to do another experiment In whtch a single dose wll I be given two hours before the LSD. , .. I. This is a scanned, black-and-white document page with typed text. The text discusses experiments attempting to block LSD reactions with BOL. There is a handwritten annotation in the top right corner, a circle with the number "96" inside. The bottom right corner has another handwritten annotation, "4-343." There are no photographs, stamps, forms, diagrams, or tables visible. The document includes some scattered dots and smudges, but no significant redactions or visual evidence of experimental procedures, equipment, or facilities. The page is a typed document with a handwritten annotation at the bottom right that reads "4-342". There are also some faint, unidentifiable scratches and marks scattered across the page, but no photographs, stamps, forms, diagrams, tables, or redactions are visible. The content discusses the methods and conclusions of an experiment involving LSD and BOL. The document is a single page of text, likely a transcribed report. It features handwritten annotations at the top, including "Page 3" and a crossed-out word, "BA." A number "4-339" is written in the bottom right corner, also in handwriting. There are no photographs, official stamps, forms, diagrams, tables, or evidence of experimental procedures or facilities visible on this page. The content appears to be a continuation of a discussion related to an experiment.