Doc 0000176562

........: -:.:.;;:.;:·· .... ~-::' :::.··~--=:-:~· -----~~~-~·.:..::..__; ~ -.~:.:..;.~..:;·.:----· ··<>··~-~~..=..·~""-:-=.:'---·;..~~-, .... _,,_,_,..,._. . --··--·""·' -· ··---- \-- ATTEMPTS TO BLOCK n-tE LSD. REACTICN BY PRETREA Tlv\ENT WI n-t SOL FOR 1\YJO· DAYS ,· These experiments were carried out because of the f . reports of' Glnzel and Mayer-Gross that 2 day's pre treatment with SOL completely blocked the LSD reaction and one-day's pretreatment with SOL attenuated tt. Because of" shortage of SOL, only 8 subjects could be used. Stx of these subjects had not had LSD before. Insofar as was possible, we attempted to reproduce the experiment of" Gtnzel and Mayer-Gross. The drug combi nations used were: BOL placebo and LSD placebo; SOL and LSD; and SOL placebo plus LSD. Combination ·of SOL plus . LSD placebo was not studied because of the shortage of materiel and because tt was believed that the results would be essentially similar to those described under acut~ admtntstratton of ~L. BOL was given orally. l.mg. was given three ttmes dally for two days prior to admtntstratton of LSD, and a n a d d i t to n a I I mg • wa s g 1 ve n t wo ho u r s p r to r to LS 0 • Dose of" LSD ·varied between 1-2 mcgm•/ks·• of bodvweight. Measurements Included threshold for kneejerk, pup t I l a r y s i ze , r e s t i ng s y s to I t c b l o o d press u r e , r e s po n s e s A-Jyf -·-:-·· --·.-··· --- ·.- --~ . ' .. • •••• : £''~"~~~'::::_·: .. ~.~*:~7ii#&si&&M'IIij_1z:~e-~*i* &_::::::_~, ;)'~.'Nt~=-~-c:::l 1lli1~~~e«~~·0'4QI ;;\IIW1t%;!!i?"":~~;e, "'.:~:~;:~,:: ... '".:,:: ·.~­ i'Bt.,:: '1 ' --.!-~"--· -~·.:.-..:..:.,.._ ~.- :...:. - .. ___ ,._ ---- .. I o··" EFFECrs UF r\C,f. .. \INISTE!( lt-.G 3.0 i-.'iG. UF BOL 0;~ lL Y FuR 2 DAYS BE FORE LSD 1.0 mg. of BWL was given three ttrnes daily for 2 dovs prior to LSD and an additional dose given 2 hours prior to LSJ. Dosage of LSD varied from 1.0-2.0 mcg./!cg. {"ve. 1.4 mcg./!cgJ. l Figures are means standard errors on 8 subjects • .. • The image displays an ornate, metallic vault door on the left side, rendered in shades of gray and blue. The right side of the image contains text in white and yellow font on a black background. The white text explains that the document was obtained from "The Black Vault," a database of declassified government documents, specifically from the MKULTRA/Mind Control Collection. It notes that over 20,000 pages were declassified by the CIA, and the collection is available online at "http://mkultra.theblackvault.com". There are no photographs of people, locations, equipment, or subjects; no handwritten annotations, signatures, or marginalia; no official stamps; no forms with filled-in fields; no diagrams, schematics, or organizational charts; no tables or structured data; and no redactions or obscured content. Additionally, there is no visual evidence of experimental procedures, equipment, or facilities presented in this image. from 1.0-2.0 mcg./!cg. {"ve. 1.4 mcg./!cgJ. l Figures are means standard errors on 8 subjects • .. • The page is a typewritten document with handwritten annotations and a stamp. The text discusses attempts to block LSD reactions with BOL pretreatment. There are two handwritten annotations in the upper right corner of the page: a drawing that appears to be a person with a circle around them, and a circled number "97". In the lower right corner, there is a handwritten alphanumeric code "A-341". A small, illegible handwritten annotation is present in the lower left corner, possibly indicating a page number or reference. No photographs, diagrams, tables, forms, or evidence of experimental procedures or equipment are visible. There are no official stamps or redactions on the page. The page contains a table detailing the "EFFECTS OF ADMINISTERING 3.0 MG. OF BOL DAILY FOR 2 DAYS BEFORE LSD," with columns for "DRUG" types and rows listing experimental "MEASURE" ments. The table includes data on Patellar Reflex, Pupillary Size, Systolic Blood Pressure, Number of Questions, and Clinical Grade, presented as means with standard errors. Below the table, there is a paragraph of text describing the experimental protocol, including dosage information. A handwritten annotation appears in the lower right corner.