Doc 0000184420

15 January l95 2 HElDRAilDUM FORs •. . . ·.· . ' ·.·. - ,ro l. SUBJECT 2 Use of a Chemical Compound l. About a month ago, asked me if we could give him aey information on nicotinic acid: V-Ie have mnde a number of discreet inquiries nnd have turned up information as noted herein. This in formation COJOOS from one of the most prominent pharmacologists in the United States • He are making further inquiries of sources recoi!li1Ended Ly the indiviLlu..1.1 rrho provided this infonnation. One source in par• ticulnr is reported to be doin:; rcoenrch in nicotinic ncid nnd we may obtain evon more useful information. 2. The information pl'ov.ided is ns follows: .. The common use or nicotinic acid is as a vitaminJ it is uoed pr lncipnlly as a preventl!.tiw for pellnGTa (a ~:kin a.t'fection 1-Tith severe constitutional an1 nervous syi!lltons) in the southern part of the. US. Its therapeutic action in these cases is in developing a peychosis and dilatinr: the blood vessels. Since nicotinic ncid is a peripheral dilator of blood vessels, it nieht also 1::e U!lcd i:1 the treatment of frost bite but U1ere is no published· indication that this tj~e of therapy has evor been dev~oped an;ywhere. Hir~ staff has dore much work on u~iitG a combination or nicotinomid with privino for the treatment of schizophrenic patients. Privine is a nicotinic acid inhibitor (B hS) nnd 1 Dlthour;h very lethal in ll.l1imc"lls is not poisonous for 1 lnun.o::1n ·beings. 'Ihe nicotinomid-privino combinotion produce::~ a shock recction i;hich docs not involve convulsions • Ex periments in this have been mode on patients at a stato Hospitnl nearby but nre no longer bcinr; -c~rricd on because of tho lack of fundn .r.n:i the difficu~ty in travel ootwcon the mcdiccl. collcee laborntoriea end' the hospital. 'Ihc source d.i.d not know of other doctors or ln.born tories in tho US or nbrond 'Hho l-:oro workinr:; with this nicotinomid privinc combination or oilier nicotinic ncid cCirpounds. He could not recall having seen any publications on this subject. J l - ... OSI/ -... . . >.::~ !"'ioo The image displays a dark background with a large, stylized title "THE BLACK VAULT" in glowing white letters, reminiscent of a digital vault. To the left, a detailed illustration of a closed bank vault door is visible, complete with intricate mechanical details like gears and a locking mechanism, rendered in shades of grey and highlighted with a blue glow. White text on the right side of the image explains that the document was obtained from "The Black Vault," an online database of declassified government documents, specifically from the MKULTRA/Mind Control Collection, which houses over 20,000 pages declassified by the CIA. The text also provides a URL for downloading the collection. There are no photographs of people, locations, equipment, or subjects, nor any handwritten annotations, signatures, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures. The document is a typed memorandum dated January 15, 1952, with handwritten annotations at the top right and top left and a handwritten initial in the bottom left. There are also several handwritten "A" marks throughout the document. The form is clearly a memorandum with fields for "MEMORANDUM FOR:", "SUBJECT:", and a date. No stamps, photographs, diagrams, or tables are visible, nor is there any direct visual evidence of experimental procedures or equipment.