Doc 0000184438

.· 5'1-/l ..... ' : f I November 3, 1950 j. Subject: Gentlemen: after conferences with sentatives consideration .· ·' The proposed supplement requests an expansion of studies now in progress on the effects of certain drugs for Jlrevention of motion sickness. The sp~cific purpose of the proposed supplement is the development of methods for study of the side-effects of these druss, and of related substances, or of other d.rucs or agents, i.'ith special attention to their actions on complex psychological functions o.nd on behavior followed by the evaluation of particular drugs. The in vestigo.tion will have three main aspects: l. A survey of present kno1.rledge of methods for assessment of the behavioral effects of chemical and environ.rncntal accnts, such as drugs, toxins, o.lcohol, high altitud·3 endocrines including pitui 1 •' tary and o.drcnal cortical hor:nonc s, hJf,.h tempera tltrG, s loep loss, noise or vibrations, environmental stress, social stress, etc .. The purpose ·..rill be tho discovery of methods <rhich •.rill make it possible to measure the specific nature of the effects of drugs on perception, ... judgment, mood, i.mpulsivcncss, emotiona.lity i:lnd other intellectual ' and personality traits. 2. The development nnd testinG of o. set of methods by •..rhich such drug actions may be validly measured. For this purpose human subjects will be used under th8 influence of such drUGS as arc now known to produce particular effects on intellectual, personality . .. ..- j ·. . "' .... I and in order to test the validity of the methods. conuti~c trait~, The· three mrLjor a.pprCluchr:;s Hill rroba.bly be: n) do.y-book. o.nd observa.tiona.l studies of thrJ d'lily-lif'J o.ctivitirJs of subjects under minima.l dosn.ges, b) la.boratory in•:cstiga.tions by physioloGi cal o.nd psycholoGica.l t.ists under n va.ricty of dos·:J.GC levels, and c) situational o.nd intcr'lic'..r procedures at va.rious dosage levels. Each of these three methods will be applied to subjects '..rho differ wid0ly in intell'Jctua.l, rcrsonality a.nd cha.rnctcr traits, so o.s to find the intcra.ction of tho huma.n fa.ctor and the druG fa.ctor. 3· The tcstinc;, by nc'lns of whatever valid methods have been d<Jvclopcd by tho study, of such drugs as scorn likely to be in most widespread usc. It is hoped that the results of these studies may make possible decisions on the limits of proper UJc of druGs in mili ta.ry opera.tions. Particularly, it is hoped to find drugs ~1ich may safely be administered to officers other The image displays the title "THE BLACK VAULT" in large, stylized white lettering against a dark, textured background with a blue glow. To the left of the text is a graphic of a large, circular vault door with intricate mechanical details and a prominent blue glow emanating from it. Below the title, white text provides information about the source of the document, stating it was obtained from "The Black Vault," an online database of declassified government documents, specifically mentioning the MKULTRA/Mind Control Collection housed there. The text also states that the collection contains over 20,000 declassified pages from the CIA and provides a URL for online access. There are no photographs, handwritten annotations, signatures, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures present on this page. drugs as scorn likely to be in most widespread usc. It is hoped that the results of these studies may make possible decisions on the limits of proper UJc of druGs in mili ta.ry opera.tions. Particularly, it is hoped to find drugs ~1ich may safely be administered to officers other critical person ~nd nel ·. .· hose pcrccvtion, judonent, discretion o.nd decisions arc vi tally ll.1portant. But the signif.;ica.nce of such vork, if it has a success ful outcome, mny go far beyond such specific questions. It may mnke contributions to each of the areas of investiGation of the effects of chemical and environmental agents mentioned in (l) above, to problems of interest to the mental health authorities working on the effects of endocrines or on tho usc of as nn aid in drUG~ the process, a.nd to fundamental behavior theory. psychothcra;~cutic It is obvious that this task is a difficult one, having br:=en the objective of ma.ny scientific workers for sixty years. .. Bccetusc of its scope it 1.rill require tho coopcrnti'JO thinJ<ine; and efforts of o. number of sciences. Furthermore) it. is not now pos sible to foresee a.ll of tbc needs for equipment, con spo~ific sultn tion or personnel. for those ron sen:; the burlr,ct must be rela tively l:'t.rce o..nd. the pln.n:; hr;re prc:scntccl n.nd burlc;r-:t cateGories chown should be rr;gardcd as subject to l:l.t(;r rcvi::> ions. ,. , .... This document page is primarily text-based, with no photographs or diagrams. It features handwritten annotations in the top right corner ("A/B, 1, 54/1") and in the left margin ("H-B/1", "B", "C"). There are significant redactions, indicated by black ink scribbles, obscuring portions of text throughout the document, particularly in the header, subject line, and body paragraphs. A page number, "(42)", is circled in the bottom right corner. No official stamps are visible, and there is no visual evidence of experimental procedures, equipment, or facilities. The page is a textual document with no photographs, diagrams, tables, or forms. There are a few stray marks that appear to be typographical errors or artifacts from the scanning process rather than handwritten annotations. One notable visual element is a circled number "42" in the bottom right corner, likely a page number. The document is typed in black text on a white background, with no visible stamps, redactions, or other official markings.