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This document, a memorandum from 1953, discusses the ineffectiveness of known substances as true alcohol antagonists and suggests that certain stimulants like Dexedrine sulfate can mask alcohol's effects.

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The provided image is not a declassified CIA document. Instead, it is a graphic displaying text on a black background. The text announces that the document was obtained from "The Black Vault," an online database of declassified government documents, specifically mentioning the MKULTRA/Mind Control Collection. It states that this collection contains over 20,000 declassified pages from the CIA and provides a URL for downloading. The graphic also features an image of a vault door. There are no photographs of people, locations, equipment, or subjects, nor are there any handwritten annotations, signatures, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures. G-' :rr:::~c:?J.!~mr ?OR: Direct0r, 19 i~.ugust 199 -· ' . 1. Attention is c.ir!'!ctcd to y.;ur memcro.nd,..:n cnti~.led "Alcohol Ant'? ~·:mists," dated 5 Ju~:r 1952 ancl directed to Chief, ~-~~dical Staff. c,.,M,..,rehen:;ive revieu of current !':ledical li ter~:tt:rc h~s not rev~a.lP-d a ::~r;le specific and reliable alcohol antagonist that ful~ill.s your '· require::Jent:::;. ...... 2. Dexedrine sulfnte, rerYi tfn~ and benzecrinP. ~.re the most effective aYaiJable d.rugs for this purpose in the order given. Specific:o.l1y the:::e d::-ugs a::-e not true alcohol antag'"~nizts but serve to !:'.ask t!:e effects of Al~chol in the hw.z1n subject. P.ny of the rtbo\·e d::-urrs in d0se:::: of 20 rr..g:71 ta::cn an hom· !::eforc and ever:.· f0t'..r hm.:rs t·:hile inr:~Jsti:-u:; a.J.cohol::.c C€:':eragss '..'auld partiall:" counteract th'3 discer!lible effects of etl:yl alcoh-:>1. ., The on1:.r eff~cti-.re and 0pplicc.ble adsorbent is tb.t found in ~. Jarr-0 quantities of .!"'rotein either in tbe form of animal protein or :r.ilk; - e. r., a hea~:y protein :neal reduce::; the a.bs,rption of n.lcchoJ frcm the -;o di~~sti ve tract by per cer.t. !-linern.l oil or olh·e oil ir: i...-o cmnce do~e:5 '.!ill effecti·:el7 delay the absorption of alcohol but will not nrevent i ~". L. The 3-c-:~rrcl!=!x ·.;i~.~'llns definit.;:::Jy acceler;:te the :::et.atolis::-1 ~f Rlccr.ol b:,- -:r.~ lh·e:-; h~:,;ci:er, ti:e t:navailabili ty of or::.l r:r~ror~:.ons , ... . .. . . , l r . • '- her .. - J e dr'' V '" L " ~ S - ; • , . . L , • v he , .. .. - . : .. n .. . . ; . v . l.·ve r \. : .: n ., . w ,. e . ,;;,) . .. .~ . .:. " ... 'Ce' . " .; " )~ " c~ " r \ · 1 - an £. r ...~ l o. " ~. " .o. h . e , ' . "" . "" , " . '" , '! . ~ . r, ' . - , ' u 1 - - ic " + '-'C ., J · . o 1~ e .. \ . . : . : ·~ . . • , • e :-:ec-cs:-::>.17 :~::- ti:<::ir :J.ctin.n ·.. u ,ulti nin:LTi::e their vall:e. The :.nsuli!l- ... _ - glucose Ul.i::ct:t.:=-e is of dcmbt:ul value nnd i-IOuld be ill-advised because ti:e insu~in !':'lUSt be given by injection. :--. Tn ~ur.J.Jnary, the r.1ost effecti·:e avaib.blc The document is a typed memorandum on plain paper, dated August 19, 1952. At the top right, there is some handwritten annotation in blue ink. The body of the document contains a numbered list of points discussing alcohol antagonists and their effects. There is no visual evidence of experimental procedures, equipment, facilities, photographs, stamps, or forms. : . : ·~ . . • , • e :-:ec-cs:-::>.17 :~::- ti:<::ir :J.ctin.n ·.. u ,ulti nin:LTi::e their vall:e. The :.nsuli!l- ... _ - glucose Ul.i::ct:t.:=-e is of dcmbt:ul value nnd i-IOuld be ill-advised because ti:e insu~in !':'lUSt be given by injection. :--. Tn ~ur.J.Jnary, the r.1ost effecti·:e avaib.blc ;,ct)-od of co:.:.~ batti."lg the e!"!'ects of alcohol -..;ould be the combination suc;cested helow: :=-6 ·. a. to bJets of concentro.ted B-complex '.ritn.rtins. ~n· ·the tr.at the alcohol ingestion i::; to take place. ' \ b. 20 mgm dexedrine about nne hour befor8 bcrinninr. the inr,':!stion of nlcoho] ic bcverc..r-:e:; and 21i mgrn every four hours while partn.kin~; of :ruch beveraGe:>. c. l'hc ing~:;ti.~n of a he~~;y pr'Jtein ::1en.l ::hort}y befor~ ra::--tal:ing 0f al~cholic beverage~. (Alternatives - t·.;o (!:1sses ·,:hole nilk; one tilass crear:; lart;;'? heJninG ic~ creac; two ounces olive oil; or two ounces ~neral ,· oil.) - , .... - _., .. , .. ··-· .. .. 6. At the rresent ti:ne there is 2.ittlG ~ttenU.on in !'1edic:1l reseorch ceinr; directed toward countera.ctinr, the i.'r.. r neC.ia-Le er~·sct.::: of alcci1oJ. in order to :;-..'l:i.nta:'..n sobriety. This fieJd mElY ".l<:!.rrant further investigation by the aprropriate division of the abency. 7. In this r.1emor:.nclurJ ue have attempted to e:rtract the salient factors ~o:rtimmt to T~ur problem. This office would be rlea~ed to confer -.~ith your ~taff regortl:i.nr, nore detailed inforiration if so de~ir~cJ, 'end· to a.::;:::"!st you in the solution of ~ny proble~s of a medical nature ...... hich night arise. /7._ .- /( All:o-- Distribution: - Ori~ and 1 .!..~.dr~ssee C/~::3 2 - A.L/!!D (file) RI - .,. - .. ' t ... • -~ . ·-·. .. ~~- ·· .. -·-· ..... -.. ~:-•. •· . -· ....... .. .... _ - -r-...... __ .... -. .. 2~ Sc~tsmb~r 1?52 ,. Alcohol 1\nt:)c:cnists c-- •.: ~T~o from , same SU ' O J . 8C . V .. J 1952. !. Prol5mi.n~.ry di:.;cussions ht:~.ve been hel :1 ;·1i th - Chi r:f, r:hemi cal ~)i ·:is i on/t'TS re ;n.rd.; n·~ th~ d~~~lonmcnt of a iese~rch project; S1lb.jcct, 1\lcohol A.1. 1to.r.onistn 'lnd Accel'3r~tors. . . : . . .., 3oth ClTS and the ·:~di r::al Offic8 !'o.~l t•:.et thi;; ~ro ;.;lam i. s ~·:orthy of f·1rth"r in·;'"sti;::::'l.t.icn pro•ridod tha':; tl:.<>.r':' 5 s n.n CD<:?r~·.:.cn<>.l n<:?ed for su~h :.;ul;,st~J.nc?s. Tt s!wuld be noted that :::uch a ?r'll.4ect •\ill r~rnir~ The page contains handwritten annotations and typed text. Two instances of the letter "A" appear as handwritten annotations. One is near the top right of the page and the other is near the bottom left, followed by "ALD". Another handwritten annotation near the top right appears to be a signature or a set of initials, followed by what looks like "/SSD/AL/ND." There are no photographs, forms, diagrams, tables, or visual evidence of experimental procedures. The document appears to be a memorandum with numbered paragraphs and a distribution list. 1\lcohol A.1. 1to.r.onistn 'lnd Accel'3r~tors. . . : . . .., 3oth ClTS and the ·:~di r::al Offic8 !'o.~l t•:.et thi;; ~ro ;.;lam i. s ~·:orthy of f·1rth"r in·;'"sti;::::'l.t.icn pro•ridod tha':; tl:.<>.r':' 5 s n.n CD<:?r~·.:.cn<>.l n<:?ed for su~h :.;ul;,st~J.nc?s. Tt s!wuld be noted that :::uch a ?r'll.4ect •\ill r~rnir~ consider"ble bacic resea::-ch and testinr: • .. :,. Tt is r·ecc··C1~"!ndr:ri t'-ln.t TJ11r ':'fncn "!'':'r::'"lr~ n r0r"! rln"':;'l; l~"d - ::-~q·:: rr:-mont for_ sut:rr.iss5 on to (;J-. i ef, ':hemi cn.l T)i. ·-i. sion/nTs.. :;o th..,t :);d~mir.e;y :::t11~ies n~:r :,r; i.nstjt1lt:'3d. T~1c ~·0dl.c--l r~"fic'J will be .ha?O~( to assi:;t OTS 5 n t!1'? mejic~ ,:;>vnluation of thi:; ~ro.i<Jct 85 needr.:d • ·------.• . . ---- .. .--?!--· ~\:r-~:~·· :-er~:.-:.: .. ::··-~. . ~-..:.A.~ :·~~-- jlf-~~~; ·:r~. - A:3r.~ r:tnn.t_ :'e:;qt~r ~or /:.~e die t;.l Of ti ce Jistribution: Or:i '~ e..::d 1 ,\·:iirCSS€~ l - ?.I 2 - fil~ --..._-- --~~--;-~-- ..... -·-:-........ -.. _ _ _.. -· .- -~- -- :---:----, _ ____, .. _--~--- - -- ---- ~ .. -~· .. _~_\ );~"' .. ~ . II t.lco~r:Jl ,'lnt~~on.i.st.L1 ~Hlf~ t.cr.''lflr~t~r•', h.:::en.rcll r.nli !.'~V!?ln,1'':0:'lt.. !'r?jcr~t. I . l. Ha!onnee ic made t.o the :n~t'~l.n d11tod l2 ~e?­ .... t~n~'f!r 19'::'-2 fr'=""' tr.~ ~az;i~~ t.•:> t..l,c ~dlca.l '! Ctlco, ! - :'·' a ~0?)" Of nhlch 1.1~~ t.letllr,rut~.P.cJ fl')r ~;.·:.;, :Jf)d t.~ th'! MC~'H)"Vlthn d::.t.cd 2) ~.c,.,U::-:b•:rr l:62 fr~, t.he :·!cd.~cnl '.,.f!i•:~ t.1 · nr.~ t.tlttc r.mt. co-:1-:ti" ~.rie'Y":: n:&•J.i.t.. . ~ '"i·~ .rnr~ dlr-;c:·..:s~.lm\n ! IJ.f t.!1.:t ]!('dtcn.i .:'rf!e-:'l and err:..., . :"htcf, Cbc:1lc~J. L.t·:h:ia>:, C:?ncc-r!,.t!1f t.~~c· tt, . ..,'\"'~ ~i..,_ttcr. .tt. ls t.hn bt:L.~f of t~1i:1 ~tarr th.::1t th'!ro i:. ~:~nfflci'~nt o:mr:t!.io,..·lll ~"'t-eu !~ u.seablo :dc.:>h"ll <mtnr:nn.tst~ and Gccclerntors t,.., jus·t.1ry the 1nst.i.tl1t.io:'\ or n roso.nrch ot•rJ,iC'Ct to ·dotoMi!'O the fOilGibili t.j of d~vnl,pi!l,: Di.!Ch :;-.;.~­ - St:mees, ! ! the ua3le t'03Gn.rch intilc-.:ttou thAt develcr~nt 19 w reM~ ble f~ Ielt. th:'\t l t. should 00 ftY.t.~"'1dl"d to r!•!vclo~ r..rl~(l ;.,_ t ':' :, .JJ~ t ·p•.c-:-:; t n tJ-, l..ti f:t ~l/.!. I i '?. lh1r. :.~a.ff, r.:'. .t} t·) .lr.w!~ ''f t€t•:·:7'~C:ll f' n "' c ~1 :J ; . { l ,_rl.!..j' \It~~ I t.~f~ ~ :t,joc~, l~ 3~:c-..!"1D.t. '1r.nr!l ::::'l.?:X'U -~n l)l"Ci):UO.\ ar1t,~~l.l<td r,r I rcq:UI-crr.ont :Juch a i}t"'Jject. J. A. d!nt.~·nr.t o~rnt.iryniil t•eed ,.,,ll~ bG, s~rveJ b7 th, .... - rlevc 1-:>,-,:-,rmt o·f S!lbat:u,c:es h:Hl.l"& t.he f:)lla~in;~ iJM;:>.:zrt. !.1:!'1: e. fho~1'>l The page contains a typed memorandum with handwritten annotations at the top and bottom. The top right corner has handwritten numbers and letters, possibly a file reference or date stamp. A handwritten note "A" appears in the margin next to section 1, and a similar "A" is present near the bottom alongside two other handwritten "A"s and a "G" indicating a signature block for an "Assistant Deputy for Medical Office." Official routing marks or stamps are not clearly visible, nor are there any diagrams, schematics, tables, or visual evidence of experimental procedures. The document appears to be a standard office memo with some administrative markings. "' c ~1 :J ; . { l ,_rl.!..j' \It~~ I t.~f~ ~ :t,joc~, l~ 3~:c-..!"1D.t. '1r.nr!l ::::'l.?:X'U -~n l)l"Ci):UO.\ ar1t,~~l.l<td r,r I rcq:UI-crr.ont :Juch a i}t"'Jject. J. 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It :t.r. i.:··:l!r.vcd t.:·a.t t.hit: ~;o'"l.''-ci·. ~•i.;-ht.. ~··~l L :,, ••-::,>Jr! ~ "). . .,rt ' r,! !'::-~j•"!<:t .•. ':"!' !C~!fJ:<:·;·. ,.,... .. ........ __ .. __ , This is a scanned page from a declassified document. The document is primarily text, with some handwritten annotations, including a numerical code, "A/ I, 64,29", in the top right corner. There is also underlined text, indicating emphasis or specific points of interest. The text is organized into numbered paragraphs addressing a research project on "Alcohol Antagonists and Accelerators." There are no photographs, diagrams, stamps, or obscured content, only the typed text and handwritten markings. This document page consists of typed text overlaid on a plain background. The text is divided into sections labeled "ACTION" and "info collen tat". There are several handwritten notations, including checkmarks and what appears to be a signature or initial. Horizontal lines above and below some of the typed text suggest either form fields or dividers. The overall aesthetic is that of a scanned typewritten document.

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