Doc 0000017380

"' . 1 -""""'~'"'"'· .,. . ;.~. .. ~~-.... ~··-~ I I • 1 TO: TSS/OC ~ '' z. P1.wpoae of l-"')ro.i¢ct:}~O~&W4lPA.ttt.w.;\y~--·~ (L_ =·=.---- ' 3~ PJ.•o3~cr;s to Dalto: ~~~.ti~~!?&~-2~:¥. .- ~-~~-~--~ li'HOM: TSS/CD -- , -.' . -..,.~~~~~·<¢w:=-~""~. . '<~,./'-~· -~,~~,.,.~-·~·~-·-"-'1 1! j i f .:, ,. f i ' 1 ~ ·I 1 .; ! ; . I' ' ' . . . . . . ~.,.;, ... ~;;,r,~.;,.~-'~•...:-,.;.:_~. . ..._.~......:.....,..""1\,. ~""""""""'"";,.::~.;......,.:;,_,-;..~:ll"o"..,-,~~~"~~ • .. A v r. . :( ..: .. ., .~.\...1. ~ •\ it(, n:~·;;e o2 c.··~-r,.:;_r,::~)• c::\) . . ..,• .! \~1.~:;1!-!))~::.~:c.-~-=~:t(.i?. CGT"~--~;~-:1 ··· ••• }";.':"'·!·~"·\"::: :::J •• • · .• ..C.-.: ,_.- -;-}-.:~.:r;:.·-·:~:tc-1:~ ,_,., '"' v•·· ____ .__. . .- ---·~'"•' •···~-'~·· --·~··~m-~ ·-·~ -~~·~ .-.,·-~--· ··--~"""'~'""jf ...-·:-·'·· ~· •·••··.·•···•·.-·~··· *"'•"• ···~·~·--• • ·-·- ···-·---1-·:····. .. ... ... .....,.,_./J"-s&.L .....< ?.~q •L -7"--d4F.<L-. ___ _ I . I -~~-~~~--~~~--~~~] l~.•~m-~--·····---·~--·~J l r·· .·· ··-.·- -· .•.:,,·:"'''' ... ...... .. .. .... :c:····''' ,o;.,oo'.C:2J:rcc·:,l~. ··--· ... ·• .. !.'~:!!?. ....... ~--. ----1-· .... ·- ---~~-------------IJ?..,..t'JJ'.<il , .... __ .,_ ... ,. - ·· :.q_ _ __ I ... - ~~-==~~~~-==--~=:r-~~~=-== :~•=--~--~=•----•--:•··--- :~:+-~---~·:.::~ ... --·-. ---·· .. .. ..... -··---·-...... --........... ________ -... ·--··r-..... __ .... .. ... ...... _.,., --. ""-~·-·------ ~--·~-r·--~ ~ ·-------···A···-~-, ~ ·······--------------·- -- ..... · .. - ... ·- -- r r _ - __ · , . . __ . ... . . _ _____ .. __ ... . . . . . . r·--·· ·--·--..... · -·· ··-".. .. ·-···· · ........ r ,. ... · .. .... ---....... ._ ...... _. ...... .,- ---~----------· -~~-- ~- ··--~---·- !-........................ ".. · ·-·--- ·--... · ~ r···>< ............... . ,. .................................... _h ________________ ... ~---·~ ........... , ••• ---------- -·· ... _________ ,............. ., .. ., ..... i. .. ..................... ,... j ~- ... -... .. . . ,. . .. .. ..... .. li -~ ,!. r,.,-:;~· ~~": ~T: ::f~: I i I .... ,. I ....• \ ~ ·. .. \ .. ·. .... - . -122 ---------------- . I'roj~ct. lf<Ul,T~.l\ -~~ ' ; i i I ~ Y.o i' ..-A 0 < ~ 0 o < •'. < ·~ ~ .. f Contractor; :. > -·~;.:,::·,·~·:<.'~:~-.:~ >;:-.:~_).~. Cost; 1 --~ l -. i - -------== --;\-=-=--~=----=-_--- --Cc1 { I () (J 1 Harch 21, 1963 .... ··· ~A_ n:.~=· Subject: of the ones t.hey are Attached is This page is a digital representation of a document obtained from "The Black Vault," an online database of declassified government documents. It features a prominent title in stylized white text that reads "THE BLACK VAULT" against a dark background with blue accents. To the left, there is a graphic image of a vault door, conveying the idea of security and hidden information. The main body of the page contains text explaining that the document is from the MKULTRA/Mind Control Collection and provides a URL for downloading the entire collection. There are no photographs, handwritten annotations, official stamps, forms, diagrams, tables, or redactions visible on this particular page. Y.o i' ..-A 0 < ~ 0 o < •'. < ·~ ~ .. f Contractor; :. > -·~;.:,::·,·~·:<.'~:~-.:~ >;:-.:~_).~. Cost; 1 --~ l -. i - -------== --;\-=-=--~=----=-_--- --Cc1 { I () (J 1 Harch 21, 1963 .... ··· ~A_ n:.~=· Subject: of the ones t.hey are Attached is vraiting for. ~-- :• () ... .. Accounting from - ··~· Heceived from Ex::>enditu.res: i.n. $ 896.91 2. :~ ,1.0).09 U::d.l1g an average of follo\~ing were fitxr-chased ~ 325.00 1 Deep freezer 21.00 1 Tonometer of· 120.00 1 tape reco:ed '{\:L ?.00. 1 oxigenator for lmter b.:1.th 1 oven and surgical 1naterial and syringes ll?.OO ·.' 61.t-.OO drugs Ph)-siologic3l material: 212.00 Levers c0nnules rr.ercurJ rnanometers from IHE:CC 1 1 6?.00 l balar1ce (to o.lg) 2,5.00 Pictm·e rolls 26.00 Paper CU"(.ter 2).00 }iercury 57.00 Surgica.1 t:l?..terial 32.00 Anin:als (c~>ts, fov1ls, rabbits and dogs) l"ood for ani~:~::J.ls ---~09 $z_L~oo.oo statewe:1t of expenditures as f c:'r'flf~/ t.ht fY'l'VIr~r.~'or ;r.:tl.t!l'iah. li.!vtl ..- ..:,1 l;~ll if~~·.,,, t (' rn;; l'(!l:.·l n·rl :-tl'·1 fl;f' i•:{pt: nell tlu'(!!) \tt:· rr, .i t;.~u t ~·cd G:l .... I. \ • ..... • J " ~·"') ~-. ----;C/ (When Filled In) Object Class -~~--- F--~----,·---~.~--·----~~~------~-------------r------~--,-----------r------------ Obl.i_sations Obligntious Unliquid.t<tL'Il Date Remark:s and References Incurred I.iquidated Balance .. f.~-~··. ..· --~-· -·--f.·-~---------·--.-·-·--·~-·--·-----"""-------------1-·-------·~-.. J------.. -.,.~--r~---···-··--~ I (When Filled Jn) ., . 0. ~ ~ ~ ~-<1.""~~~,__-,,;~~~-~,..~--=~·~:.:.o -~·~.:~_ i:c:.-~--~ .. ~-,-:~ll· • l l I ~ I : l!'lHAl~CE DIVISION I SUB.JEC'I' 1:4KUL'l'RA Suhpl·ojcct 122 1 Under the authority gt•nntecl :tn tb~ memorandum dat(~d 13 April 1 1953 front the OOI to the liD/A, end. the ext<3nsion of t~hia authority ~ in subgequent mcr.m:r:-a.ndo., Subproject 120 h~-s b.e::m o.ppr·oved t•rtcl 'j $2 000 of tl:.e ovcr~:all HKlilffR4 project funds b:~s been obltgated 1 ° to cover the subproject's mq}ensea. 'l11is obligation of i\md.s ahould be char~d to Allobuent 152)-1009-1902. It TSD/Hee-earch Branch ~1 I l - 'J.'SD/00 1 .. 'l'tiD/HB " j.... . \ (/ f '0 t . J / /.0 / \ < ) " • .. .... ,...... £&&&..... ~,.......,.._. (When Fi.lled In) I SUBMiTTED BY ---~~~-----voUcHER NO. fFinsn~e fJRA l'lnlv\ t '} ACCOU}:T!li:G BY !NDIVIDUJ\L FOR ADVANCE FROM 5 NOTE: ,. ~:· ! 1 ··· · ··-· -- ,! cer:i.fy tl••t the ""!Jetar!ituru : ---· -·-·--· -------·-- --- I -- · ---··'"·- -- I ·on any attBchment• were incurri!Jd !<>r o!fi.ci.a! pur· po••• ol a contiden:iial nature, th"t paytnent This page appears to be a form with handwritten entries and official stamps. The form has fields for "TO", "Date of Obligation", "Purpose of Project", "Progress to Date", "Expiration Date", and "Project Monitor". Several sections of the form are heavily redacted, obscuring significant amounts of text. There's also a handwritten number "122-1" in the upper right corner and a handwritten "G" on the right side of the page. The document is dated, and a stamp indicates it is "CLASSIFIED". The image is a declassified document with visible handwritten annotations and a form with filled-in fields. A number, "122-2," is handwritten in the upper right corner. The form appears to be a financial or project tracking document with columns for "Date of Original Authorization," "Period Covered," "Time Extended To," "Allotment Number," and "Amount of Obligation." The visible entries include "1 Sept 1960," "505-10T9-1802," and "2,000." Another section of the form is labeled "Invoice Number," "Date," "Amount," and "Balance," with an entry of "19 Sept 1960." There are also some redacted or obscured areas within the document. l'lnlv\ t '} ACCOU}:T!li:G BY !NDIVIDUJ\L FOR ADVANCE FROM 5 NOTE: ,. ~:· ! 1 ··· · ··-· -- ,! cer:i.fy tl••t the ""!Jetar!ituru : ---· -·-·--· -------·-- --- I -- · ---··'"·- -- I ·on any attBchment• were incurri!Jd !<>r o!fi.ci.a! pur· po••• ol a contiden:iial nature, th"t paytnent or credit therefor ha• not been r-ec..f!Ji.ved, and th•t · thl• accountJn; i• true and correct. OA'rE S liGN4TURE OF P4Y£E 'I :1 ~o''· i F ;,: ~;· lt·• <:R£DIT TOTALS fOP. lot 2S2 e.. 6' U$E- PIU:YIOUS to&TIONS. ~1) ... -~ .. _..-_..,_ .. _.._..._..,.~~-"-~•~;,;;:o'*"'""' a•••n GPJ,,UG<<;_4,ii!!*FQ.i,_4 .ffP1IIC8 .4.4(. I t t ,P,i,J!f41!4f,.""fi*"'1'~R_4@1JECQ4Q...,....,_.4£ (4£j!Q!TU!.J,.J (SSiiG¢;t1,.4f,Jh'!!¥R"F". ... -~~·~ ··~-"~--·'·'•·'"•••<2"'"~·~·-:p;;::;rJ1li!1elJl@t'I'N$& ... 1 ~ ....; ...< 1 1 1: 1. ''· l. If f1;nds, in the form of vther than U.S. Dollars -were on hand, received, or disbursed during the accm.mtin£. :period, all pertinent data, i.e., rate, method. of ar:quisition, etc., must be shown. If advances have bee::< made to third parties, enter the total of such advar.ces outstanding at the ·oeginning of the accou.11ting period t. il on line la. ! i 1 ~ 2. If mo:-e s:pace is required to explain receipts, prepare receipt form, number and attach hereto. In every case, : completel~ identify the source of receipts. ) ,, d 3. Attac!:"l a voucher for each expenditure and assign a number thereto in numerical sec;.uence. The vouc!".. . er rr.ay be the receipt obtained from the payee. W11en a receipt is not obtained, prepare a certificate and attach as a I' ?· voucher: When .space on form is not sufficient to list all vouchers, prepare a listing on a separate snee"t ' ~ and enter the total u11der item 3. If ad.va.nces to th:l.rd parties are outstanding at the c:::.ose of the acco~t­ I ' t: ing period, attach an itemized list and enter the -:otal on line 3a.. t['. 4. Final credit will not be given for disbursements which are advances -:o oe accounted for. When accowting ~ ·. ~~ for advances are 'obtained, list as expenditures or refund of cash, as appropriate. ~ ·, i ?. Total receipts entered on the line "Total to Account For" must agree r.;ith the total disbursements entered on the line fo:!.lowing "Total Accour..ted For.' ~' 1', ! ~ L 'i'·. Ii t· :· 1' ' I ! ~ .. -,·~·•>·..,.--...,.....,...,,.._...,. .liii.U"' ._ ,._ _...,~1=l; too;;re""' 4 """""'.,...,~"'~"'Jif. ,I :;if!4 r;ll!~"-111_i!lllllloOII,~ The visible content of the page consists of a document with typed text, what appears to be handwritten annotations, and significant redactions. The typed text describes a project, "KULTRA 122," including its purpose, initiation date, contractor, cost, and status. Handwritten elements include a numerical annotation in the upper right corner ("122-3") and a cursive letter "C" next to "Status: Unknown". Large, dark redactions obscure portions of the text related to the contractor and the work being referenced, as well as a smaller redaction under "Purpose." The overall impression is a bureaucratic record of a project with sensitive information heavily redacted. Total receipts entered on the line "Total to Account For" must agree r.;ith the total disbursements entered on the line fo:!.lowing "Total Accour..ted For.' ~' 1', ! ~ L 'i'·. Ii t· :· 1' ' I ! ~ .. -,·~·•>·..,.--...,.....,...,,.._...,. .liii.U"' ._ ,._ _...,~1=l; too;;re""' 4 """""'.,...,~"'~"'Jif. ,I :;if!4 r;ll!~"-111_i!lllllloOII,~ ,1- ;] .•> .~HW ~·:1-..... I • CONF I OSNT I AL FVNDS POSTING VOUCHER! VOUCH~RNO, 7•12 71· eo AMOUNT DEBIT CREDIT '· ,, I ~ I 1·. ~ I· I· ~ t I ~ ~- f l' r \. I I I 1 I I 1 I ! I I i I I I 'I i I ·I ~:' J I I I I I I I I I I I I I I ... 'i I I I I I I I I I I I I I I I I I i I I I I ! I I I I I I I I ! I I I .~.· r. f·~ •' f I: ~r'~n~.~v~~~-------------,,~~~-~--~-~--~-~-~-~ .. ~ ------------------~----~--------------------------------------------------------,---------------------------~--~~~~-~----~-~-~~--~---------1 -ER I ~ . . . .I> •.• - flo" . . : . "\,. -~, •.• • ...... ~ ~- ~ - ' .- 7::1..~ ,,._, ·n·. ( tO• O:lll ... •" .. I ; rr<.lJ1RR\, Gu't:.lrt'oject 1.22 lnvoi(:e {}l 1 Allotn:;nt .l.l25-1CO'?-~l9'·J~ l. !i:r11o.\.o; t;o. l .:t.s e,tt=;.~h~~i (;'l\"¢:t'1.ne t-h:'J' eor.;(.we ~.nib;rJ-t'<:•j.;;;ct. • ' I'.::~y.x::nt .:-l:ouJ•l 1<-3 1~1:~~'k~ ~<.3 f(>llClus: 1 i 1 .l ! B l I i 1 ).. 'ihio ht 0. i'itt.'.V. iavolcc. H~~F~f'/\3:e, oincc it ia o.n"hic i~_:~t.:!d. thai;. r.. . .-~:U:'.:-lo~l.-:\1. f\<~lJJ; vlll 'bo (iblise.t.-.;:0. l"'or t.hia l,>.roj-cct, i t.:m f1J,:<.s EJlC.~l.l~l. r;{.>t bl C)CK-;;>i~ .• I Chic! *Y:f!ifJ/H~Ev;o:r:--ch. Branch Dh, triuui1on: a ..... .. (:O}:i.g tl ~.~~ ~~!~$fJi).') '---7 1 'l'SD/FASS / ...·, /.· 1 ~ .. ., ~. (Whon Fiil"ri lnj SUDMITTf.D BY ACCOUNTING BY INDIVIDUAL FOR ADVANCE t:. ~~1~ i''* t~- ,i•.. ;,, .p ~ ~; k• f· '1· ~· I. l·l :~ I.'1 · DATE ~ ? . I } /,, j.~;. fl. ~~'·I 7!. ao A MOUN"'!' OI&IT C:fi'£JJT !'OR": 282 UIE :PllCVIO\IS EOITIO~S. co 8-• if 1 I --·-··----....-,. ·-, .! •• ,, ...., , "" ""* ;;z .o .. c•" , ,o; .>&> '"'· "'""'" u"'"'"'"'"'·" .o. _,.. : , ; c ;: . o• "''"i'. ; , p; U!§il>)ii1&0 3J9,$¥:U 61iiJllllii$47 1,<\F ilk :lii'9!ibf""!l\l'!lj:w&Jl""'' ••.. " / I f,;., .... -"' "'· - The document displays a memo dated March 21, 1963. There is a handwritten annotation "122-4" in the top right corner and two circled "0" marks at the top. The text includes fields for "Memorandum to:" and "Subject:", with the subject identified as "Finances". A sentence states, "Attached is an accounting of [redacted] one of the ones they are waiting for." There are two large, handwritten letters "C" in the lower half of the page, each placed next to a significant black redaction that obscures text. if 1 I --·-··----....-,. ·-, .! •• ,, ...., , "" ""* ;;z .o .. c•" , ,o; .>&> '"'· "'""'" u"'"'"'"'"'·" .o. _,.. : , ; c ;: . o• "''"i'. ; , p; U!§il>)ii1&0 3J9,$¥:U 61iiJllllii$47 1,<\F ilk :lii'9!ibf""!l\l'!lj:w&Jl""'' ••.. " / I f,;., .... -"' "'· - •· ~--'To, ~ • INSTRUCTIONS . ~ :. !f :;'1;..'1ds, ir. tl;.e form of ot'her than U.S. Dollars 1•ere on hand, received, or disbursed during the ac-::cu.."l.t:!.n;: I I ~ :;,?e:::-:..cd, all pert:!.nent data, i.e., rate, method of acquisitior., etc., must be shown. If advances have bee:: I r::ade to th:!.rd par-r.ies, ente:::- the total of such advances outstanding at the beginning of the accou.'1ting perio.l ·I' or. line la. ,, i 1: I 2. If :::ore space is required to explain receipts) :prepare receipt form, number and attach hereto. In every :::ase, co=ple"t:ely _identify the source of receipts. ~ ~i· " ! 3. Attach a vo"'..l.c'C:er for each expena.::.ture and assign E:~. number thereto in numerical sequence. The voucher n:ay be Cf ! !1 t"':1e receipt obtained from the payee. When a receipt is not obtained, prepare a ce:::-t.ificate and attach as a i voucher.. W:'1en space on form is not .sufficient to list all vouchers, prepare a l:i.sting on a separate sheet . I i a.'"l.d enter t·he total under 1 tem 3. If advances to third parties are outstanding at the close of the ac;:ou~t­ I ! ing period, attach an itemized list and enter the total on line 3a. I 4. Fir:al credit •,.;ill not be given for disbursements which are advances to be accounted for. w:~e:n accour.:tinb for advances are 'obtained, ::..st as expenditures or refund of cash, as ap:pro:p:ri!'l-te. I ::;. Total receipts entered on the line "Total to Account For'~ must agree "With the total disbursements entered on t"l.e line follo•..ring "Total Accounted For." :r· ! I I I ~ r·JJ "-'l I 1 I ! I .- ~. ......... , .. .~. ..~ ·~, .. :··: . ~ (· _,.. .. ' .. ~·; .. ~ ..•. . ...... .,.. __ ,,_..,. ....... ____ ,.,.._... __ ~ ""'•'" • _.__,...............,._..,..._.._.....,..*¥-~•""•"i ,1Qi44,11.111""1Ti ::;t51M $¥ ~ 4 :ji¢1"11'!" ... lii'.U ;Ill'. I, 144if V4 i i, lijillpA4'¢4,.,AII4iW U JS4J .. J4J .. ,..._.,. ... () HECEIPT ·Receipt is hereby acknowledged of' ~~llmdng ~heck: VIA l t:<::tfUfJ!i, ft~Jj'~•l"'j~,;;~;-'.:1.;?,.:!, In.VOiC•l 1:~1 tJJ.o ~ .. -mt :o;:;; The document is a declassified financial statement from March 21, 1963, detailing expenditures. At the top, a handwritten annotation reads "122-4." The document is heavily redacted in several sections, particularly where "Accounting from," "Received from," and sender information are located, obscuring specific names and entities. Below the redactions, the page lists various expenditures, including "Materials imported from," "Material purchased with," and a detailed breakdown of purchased items like a "Deep freezer," "Tonometer," and unspecified "physiological material." A handwritten signature, partially obscured by redaction, appears at the bottom next to the typed word "Dated" and a handwritten date of "3/27/63." The overall appearance is that of a ledger or an expense report. ....... ____ ,.,.._... __ ~ ""'•'" • _.__,...............,._..,..._.._.....,..*¥-~•""•"i ,1Qi44,11.111""1Ti ::;t51M $¥ ~ 4 :ji¢1"11'!" ... lii'.U ;Ill'. I, 144if V4 i i, lijillpA4'¢4,.,AII4iW U JS4J .. J4J .. ,..._.,. ... () HECEIPT ·Receipt is hereby acknowledged of' ~~llmdng ~heck: VIA l t:<::tfUfJ!i, ft~Jj'~•l"'j~,;;~;-'.:1.;?,.:!, In.VOiC•l 1:~1 tJJ.o ~ .. -mt :o;:;; .. letJ]-~l9'.J~ 1 •. Ir:iV'Olcc L<>. l 1>1 ~;~t-tu ..~ h. .~ J. cc·-.;-.n'ln~ tha ebo'J\; Gt:'bprojr.:;ct. P{>.y:1:nt d~ou.:hi b.~ to·:'l.::l. . :! us i.'c)J.m;;;,;: ('~:.t;h1.Cl'' Q ch:;:::k ~-n t'h:.:;:;:, 1 o::-·t a. l.('.. .; ;:Jl ·j i < b~ i'o:t."tt..!.I'Il~"l to Chl l I l ;:s..--r-.:4 c:h, b'l)~""O~) _:~li (;ff"i.CCl' 1 !:tO lD.t..Cl.~ i 3 c~:.-~:..~.t~J-1; 4l~{. .o . ! 3. . · '~'~to S.::; R flt>~U. lnV~'IJc0. IL.~-2Yti!l'; s1Ecc it fs (:.nt.:.c ... ,,.nl iJ>~t·',i t?lc~t, t'.-:1Hi.•;;;u.1• .i\;:.;r1.'J 't"J {-'bHo;t;:;:;::l :f<:>";~ thle ),'lro.~~,.,<..~t, I t~:•.1 f Uc3 nho". . .l.ld. l:i.A< l.J..J cl.G·.:>·::J.. .. -IJ,· \ t•tt.t·.•:r.::d.; ir~·:..:.l~·:z i,", Cr,;J.1!<1!'iCtJt1o;;o Dis{_ 'l.'ll:t:tion.t (Jx-.. 1!; r~ 2 " 1-·~ ll\'"~o~o 1 T.SD/FASS '/2 - TSD/R"B &~pt. ~0) TGD. ...1 9 ):}~ () I . 1 l l l I 1 (1) It ir; h:n'Cby certified tl1Lt thhl is !nvoi.cil l~o. 1 :.rppl.ylng to Sub .. :p:co~\ect t:oo 12<'! o:'? 1-:aJHt.'HA, the;~ f,tel'".i·or.:-l$.nce is sa.tiofv.ct<:.:l.-oy1 tha.t DCl~vic~s (tt'•:l ooint~ 1;\CCO;:;l)lic-hc!d in c.ccordn!lCa Vith tLUt\lLU (lf,l"eeiU~nts, j thst o. {~r::t.:.-:.ilcd D;::;cm:l& C:•f the :pa;y;~~;uts nnd rvceipts is on file in 'J:SD/ f>."\~1 the.t. this b:Ul is jU.Gt £;Ufl C\)l"l~Ct and tho.t );1~\;y:v:mt t.liCl'cOf' ilea 1 r.ot yet been lllflde. ! {2) It 1~ h'3.t·eby t:'-.!l'ti.iicd. toot thin inYoi..co a:ppllas to 8uh1)roject no. l2.~ of t~-:.uw:.a.l.\ l:i1ich \:-~:.s dlLly v.pp::t·ovod, m11l th:J.t 'tt.i'l p:rojf.;ct is boinr; C:: ;:;..r:d·~;:~ou:i; j_n_ tlCCOl·~i.t'.l1Ca Vi th tho 1!1!2l!:lOrilnd.UL;'l Of 13 t~:pril 1953 f"rom ths rX~! to th,; DD/A c.rd. the f;:x"tem.rton of' tM.a aut.hot·ity in nul,E.:eg_ue;.1t 1 U¥:::tr:.o1'andn.. 1 I I I .. ' .. , .... ,~. ···e ,-., ':"-""'-""?'""'"~--~·~,···:·, ...-···~·~-' ..... • ·~·-· -.·~···-····, ·' cco_··-~~l C] t } i i ; l I I .i; ' f ! I t t ~ t I \ l 1953 i'l'{i-"l tl1o L'Cl to tb~ l)D/A, &\~1 th'l extens1011 ot tbis o.utho:rit;y l () l;lEMORl\IiDUM FOR: 'l'BE BECOHD SUBJECT- Project l>'iKUL'r.R.'\ Subproject 122 1 It is requested that t 122 be approved to support _· ~ Univ- ,. in pa.rt the ersity with - f n nccm.·dance the atto.chcd proposal. 2. Neurokinin is almost cr~a·te.iuly f\ &\~1 th'l extens1011 ot tbis o.utho:rit;y l () l;lEMORl\IiDUM FOR: 'l'BE BECOHD SUBJECT- Project l>'iKUL'r.R.'\ Subproject 122 1 It is requested that t 122 be approved to support _· ~ Univ- ,. in pa.rt the ersity with - f n nccm.·dance the atto.chcd proposal. 2. Neurokinin is almost cr~a·te.iuly f\ _major mediator in the ·btwan 1 "stress" reaction. Its nature and function ~\re not well und.erstoo;l. _human atress l.'eactiona lY~in Succesa .tha cou:L.:i support ll!Atcrially _ .. · 4~-- -===-··==:.=.=.===cc=·------ -- --l>!K1JI.'I'RA, SubproJ-ect-61-:- : • • ha.s been briefed f:t.tl . ' M • • ~ • .. T i . e • . , - -: . . - - -·' ~ . . Bect~rity and cover purpooes.- - aMO\'llting tor :t:\lflds-eX];ienae<r-siw.Il-confol:m. to the est;abU.ehed procedures of that organization. Title to any pet"'.lln.nent eqniJ.llilent shall witli~r~~~Y ~:1-~~i~_u ~~ ~yerhead ch~1:ges. 1·emain 5. Tho total coat of thio project for a period of one year is oo est:l.mated t;o $2 000 as indicated i.n the attached budget. CJ:w.l·g~B 1 i ~ -·~~ ~ ~'""',-'!'"• ~T~ >"?fl'--,.;_ ·r•··L":':;>~;-·r ;."f'~~'r~"· '"';:T~".-::'1~;·<':..::·~~:,"-"·:··-<Q"'~·~'':ot:i'::""~ '*' ,.-{''.~.'"-~.~.-''rf.--l"'7"-~·:r-...~ -ry () () should b~ nw.de aga.inst Allotment l'iumber 1525-1.009-1902. • 6. No clearer\ c1r witlling persons e.ra concert~ed vith the or conduct t.b1a p:roject. II- APPROVED FOR OBLIGATION OF Fill."DS: ___ _ ··I ·~·-·, • ._ .. ''"··"'··'-"'·;.•~ Attachment; Proposal Distri.bution: O.dg:inal Only II ! . () () .. •·- August 15, 1960 MEMORANDUM TO e a • vbuld appear · cou consH~ ne sc fie contributi , hos worked wit~~ ! -- fL here a~ and recently · My only corornents are: 1) nally able to judge the signifi- cance of the research except from a general pc.int of view ctnd, from that standpoint, ~ it oppeors to .t t; and 2) my only other reaction is the same as is the ~obs.ervoti quest.ions the immediate rele.vcmce of this proposal to /J Jha field If this observation can be ratidnalized, then I would feel that the of the Directors and Adviser~ con lead only to recom- rt._..l endotion for approval to support this project• Program Director Enc: 2 copies of Proposal ,_ ~ -' - (} Q) . ' .. M'xt I, 1960 • . ...... . ': . _···· ~ : .1 18 . ' ' Deor Sirs: . _ I have enclosed o proposal for consideration by the ~ for s~.~port for o series of This document appears to be a ledger or accounting form. It contains a table with columns for "Date," "Remarks and References," "Obligations Incurred," "Obligations Liquidated," and "Unliquidated Balance." There are two entries in the table with dates in September 1960 and corresponding financial figures. Handwritten annotations are present, including a number "122-5" at the top right and "515" next to the "No." field. Additionally, there are markings indicating "(When Filled In)" at the top and bottom of the page. The "Cost Account" field is filled with "1.25. 1008-1802." There is no photographic or experimental content visible. 2 copies of Proposal ,_ ~ -' - (} Q) . ' .. M'xt I, 1960 • . ...... . ': . _···· ~ : .1 18 . ' ' Deor Sirs: . _ I have enclosed o proposal for consideration by the ~ for s~.~port for o series of studic.s concc .me? wit~ Neuroki~in, '~once t:1ot oppecrs to ba of great 1mportMco m tho pathologtcal ... mechanisms by which rnon•s relationship to his environment influoncos health. Sincerely yours, t ·' t.. -( •.. -· () /P!J·l) PROPOSAL I. Institution: "oeportment of Pharmacology, University o Tho control norvot,n.ystcm evokes, integrates, and mod.. ulates . . . - tho body's adaptive responses to tho onvironmont. These rosponsos nccessmy to I s~~rv~va_l ~·hen opr~ropriatc, are- implicated in tho c~iology ond course of clisoosa of ~ many .cotcgo~ios when inc1pproprioto. It is well ostoblis.hod that reactivity to noxious stimulation con be modulated by tho ccntrarnorvous systc:m thr.o ugh cor1trol of the· . t}n(ing and amount ofadrcnal cortical stimul rmorw (:,AC TH)from tho pituitary gland. Recent experiments at ha~o shown that another moior route for central nctvous system moctulation of the inflammoto1y response exists. This latter route is through vasomotor control ond through modification of iho magnitude of local,ncuronal roflcxo1. A potent vosc,dilator substance is implicated in these reactions, ·~- The applicant hos boon one oft ho hos defined thi$ biochomioal svb.$ttn'\ee os ncurokinil'le Neurokinin oppcmmtly is a vo~odilotor polypeptido formed by tho splitting of o protoin {globulin) present in oxtracellulo r fluid~ This splitting is duo to tho action of a prot:o:)lytic onzym~ (t1ovr:JkJnin forming On7~)'1)1e), . . possibly an intranouronol proto,lso, Tho somo cnzymo hos boon C'bsoJVcd .o 0 . ·. -2- in tho cercbrospincd fluid ond in perfusate of the cerebral vontrido during stimulotion of tho o of brain, thus giving source tho motorial for study. A crude prcpmotion of powdered neural-·- kinin hos been propored by incubation of.-gl.obL•Iif1:y/itln:orebTos-pinof fluid collected from pa ticnt·s VJith schizophrenia, which contdru)lorge amounts of neurokinin-forming enzyme. '\ . . --··- - ! -··- Tho oj)plica(ion has worked h. . d€finltien·~Hhis CYJl€n.t al'id in the preparation neurokinin. e) ~-edi~-~O bi~9~,e~· · T<fpropdrc and chorddcritc highly pvrified neurokinin by chromotogrophic chcrnieal methods. · To-defin<flho pharmacologic properties, and contribute to understanding-:.--~-=---==­ of thEl physiologic~l and pathological significance of novrokinin. II. Methods a) Obtain nourokininfo-rmins enzyme from humon cerebrospinal fluid and from perfusate of cerebral vontridos of lab,orclory animals The document is a memorandum dated September 9, 1960, concerning MKULTRA, Subproject 122. It is an official government document with typewritten text and handwritten annotations. There are no photographs of people, locations, equipment, or subjects, nor is there any visual evidence of experimental procedures. The document includes filled-in fields on a "CERTIFY THAT FUNDS ARE AVAILABLE" form, along with stamps, and a signature. Specific handwritten entries include a date stamp of "19 SEP 1960," an obligation reference number, and an allotment number. There are also various official-looking stamps and what appear to be redactions in the form of dark, obscured boxes and lines. The image shows a financial form titled "ACCOUNTING BY INDIVIDUAL FOR ADVANCE." It contains several handwritten entries, including dates like "5 October 1950" and "21 March 1953," dollar amounts including "$2,000.00," and signatures labeled "SIGNATURE OF AUTHORIZING OFFICER" and "SIGNATURE OF APPROVING OFFICER." There's also a large letter "A" written in a box under "SIGNATURE OF PAYEE." The form includes sections for receipts and disbursements, as well as an "APPROVED" section with a certification statement. No photographs, diagrams, or visual evidence of experimental procedures are present. neurokinin. e) ~-edi~-~O bi~9~,e~· · T<fpropdrc and chorddcritc highly pvrified neurokinin by chromotogrophic chcrnieal methods. · To-defin<flho pharmacologic properties, and contribute to understanding-:.--~-=---==­ of thEl physiologic~l and pathological significance of novrokinin. II. Methods a) Obtain nourokininfo-rmins enzyme from humon cerebrospinal fluid and from perfusate of cerebral vontridos of lab,orclory animals during stimulation of tho brain. · ~) Preparation of .crude neurokinin by incubation of corebrospinal fluid with globulin, precipitation, and extraction with alcohol. c) turification of tho crude proporction by p<1por and column chroma- togrophic separation of tho components it'l tho crude preparation. d) Pharmacologic studios to identify the active fraction a. isolotod rot uterus, rot duqdonum bioassay and ossay of depressor action orl tho blood pressure. 0 .. . () -3- . . cj Phormaco10gtr· .-·charCittcrkoti;;il of tha propc:rues of putifi, nq;uwkinin. I) Eloctro~ncephalogrop.hic changes induced by intraventricular and •m t"c'r~c arotl" d • In • IC C t"w n •m t1n e cot. 2) Behavioral changes ind~~ed by intravcnf'riculo.r injections of . . neurokinin into ummcst~.~thed cots with implanted intraventricular cannulae. ____• · _ Ill • It is expected that these studies will require one year to complete. IV. . . . . - . . . , a}· A pparotus to augment equipment avaiJ:orble/ 1in 3th ; . . .. '4 •• l • • . ~ • ' I) Stereotaxic (Hvrsoly Clark) opporotus for perfusion of cerebral ventricles ond for p!Gcernent-of intraventricular connvlo~ $900;00. 200.00 3) Small polyethylene Tubing 50.00 __ ----- ----- 4) R~cording kimogroph for smooth musdc bioassay 250~00 5} Miscol !ano_ovs cqviprricn~ ~n1onori1ator ,don1ps, 100.00 cannulae · b) Drugs and supplies for electrophoresis. a·nd for phonl\(lc.ologic studies · 300.00 c) Animals, animal fo;d, and cogos .. 0. , . () ' ... '\ "' ~ t -:4- ....... .,. ..... ,.·.~-~ -- ., ..... •''-'. - v. oftho.---:F ;·. is~-tox excmrt organization . Tho author is engage - d - in a f . ll ll_ time m - seor -- ch -- a - nd . teaching. Ho has worked os . . . . e - ~ ~: a professiona . . ·. . ' . ' - . " . . or~oots and·hbs worked spc~ificolly with vosodilotor · _______ _ rocen~ly "He has completed withn-eurokrnin " foikwshipw and bocowing acquainted with tho point of Vif:W rogram. ;_. VI and VII~ This project has not been undertaken proviously and no support The document is a scanned page from a typed form with handwritten annotations and a partial official stamp. The form itself appears to be a set of instructions, with numbered points detailing procedures for accounting for funds and advances. A handwritten number "122-8" is located in the upper right corner, possibly a document identifier. There are no photographs, diagrams, or other visual elements besides the text and annotations. The content is focused on financial and procedural instructions related to the handling of funds and advances. . ·. . ' . ' - . " . . or~oots and·hbs worked spc~ificolly with vosodilotor · _______ _ rocen~ly "He has completed withn-eurokrnin " foikwshipw and bocowing acquainted with tho point of Vif:W rogram. ;_. VI and VII~ This project has not been undertaken proviously and no support has been o·r is being requested of other foundoti ons.--- 1 . () (_) ' . PROPOSAL .......... ~~~~......,.~ 1. Title Tho control nervous system evoke~, integrates, and modulates the body~$ a.Joptivo responses to the cnvironmcmt • These responses nocessory to --- 1 s~rv~va.l :when op~roprioto, t1rc imp!icotod in tho a~iology ond course of disease of many _catcgo~ios when inoppropriCito~~~ If ls well-establisl;cd that readivi!y to noxious stimulation con be modulated by the ccntral·nervou> system through control of the tinung and amount of adromd cortical sti hormon~ (:~AC TH)from the pituitary glond. Rocent experiments at tho : shown that another m~ior route ~or contra I nervous system modulation of the ir.flammotory response exists. This - - latter route is through vosotnotor control ond through modificat-ion of the magnitude of local, neuronal rofloX(l.2. A potent vasodilator substance is implicotcd in iheso reactions. The applicant has b(;lQI"' one of tho invcstigd:ors who has defined this biochmnicr.tl $ubstonco as neurokinin. Neurokinin apparently is a vasodilator polypeptide formed by tho splitting of o proto in (globulin) present in extra coli ola r fluid • . This spli~ting is duo to tho action ~fa prolo~lytic cn:z.yml) (ncuDklni~ forming (.mzy91e) 1 possibly on intrancuront1l prutoaso. lho samo enzyme has been obsorved --~------------- () () -2. .. in tho corcbrosp.inal fluid and in perfusate of the cerebral ventricle during dimulatlon of the brain, thus giving a ~ovrcc. of the material for study. A crude proporatlon of powdered nourof. kinin has been prcpmcd by incubation of. globulin with cerebrospinal fh.•id collecte