Doc 0000144761

, Chief, Contact Division 8 January 1952 ... tor Bcientitic Branch . Chief, Ott1ce II I Caae # 1. As recommended 1n case , ve have discussed the uses or C- · nicotinic acid and its compounds vit h /) who is head of the Department of Pharmacol.ogy at the Medical School in I .,C - vu moat cooperative and made the tolloving cOIIIIDI!Dts 'I on the subJecta 2. The common use ot nicotinic acid is as a vitamin; it is used principallY as a preventative tor pellagra (a skin affection v1t h severe constitutional and nervous symptoms) 1n the southern part ot the US. Ita therapeutic action in these cases is in developing a psychosis and dilating the blood vessels. 3· Since nicotinic acid ie a peripheral dilator ot blood vessels, it might alao be used in the treatment ot frost bite but there is no published. indication that this t1})8 ot therapy baa ever been developed anywhere. . ' ' ' t3 4. The starr of the . Medical School Pharmacology Department has done much vork on using a combination of nicotinomid With privine for the treatment or schizophrenic patients. Privine is a nicotinic acid inhibitor (B 45) and, although very lethal in animals, is not poisonous tor human beings. The nicotincmid-priTine combination produces a shock reaction Which does not involve convulsions. Experiments in this have been made on patients at t3 -· Hospital in ' •. · -- --- . but are no longer being carried on because ot the lack or 1\mds and the difficulty in travel between the medical college laboratories and the hospital. c oth8r 5. did not know ot doctors or laboratories in the US or abroad vere working vith this nicotinomid-privine combina ~1o .. tion or other nicotinic acid compounds. He could not recall having seen any publications on this subject. 6. This office believes that it might be advantageous to discuss HvC. Case - vit h ,, Chairman ot the Bio-chemistry Depart- 1!J ment of the ~ llhere we understand research in nicotinic acid is also being done but, because of the aensitivity or the matter, ve will not do so until further advised b1 1ou. ! .. - . • I . \ sg ~: . . I --:.- · - . ~ . · -· · ·· - ·-~-..· · ' · .... ·~··· ' • ... :- ··-··· The image displays a stylized graphic that serves as a header for a declassified document. On the left, a detailed illustration of a bank vault door with intricate mechanisms and a glowing blue light emanating from within dominates the scene. To the right of the vault, the text "THE BLACK VAULT" is prominently displayed in a white, slightly distorted font against a dark background. Below this title, a block of white text explains that the document originates from "The Black Vault," an online database of declassified government documents, specifically referencing the MKULTRA/Mind Control Collection. The bottom of the graphic features a yellow, clickable link to the website. This visual presentation suggests the context of sensitive or hidden information being made accessible. The document is a typed letter with handwritten annotations in black ink and blue ink. The letter is dated January 8, 1952, and is addressed to the Chief, Contact Division. It details information about nicotinic acid and its uses, particularly in medical research. Handwritten markings appear throughout the document, including checkmarks, underlined text, and what appear to be initials or other shorthand notations. There are no photographs, official stamps, diagrams, tables, or visual evidence of experimental procedures. The document contains several handwritten annotations which draw attention to specific parts of the text, but their meaning is unclear without further context. the aensitivity or the matter, ve will not do so until further advised b1 1ou. ! .. - . • I . \ sg ~: . . I --:.- · - . ~ . · -· · ·· - ·-~-..· · ' · .... ·~··· ' • ... :- ··-··· .A• .-... ~ • ·------···-··----·-···· ----· -- 19m :z- :z 7 j- '( ,._ / I -' afa~ F'OII:M ,.., .\ \ OJ)ice 'f4enzora1,zdu1n · UNITED STATES GOVERNMENT TO l:Liei', CL•ntar.:t Division DATE: •..: J~·n )2 Atl.eution: Depnt:,• Chief G Fl.O M ,_;hief, Office H SUBJECT: C::1se /1 He: , same ctrb,jcct, cbtell ~24 J..:.n 52 1. The nicot.inomid a.nrl. !Jri vine cornuiuatlon is not u. cu1apound. '!'he two separate •lrU[;s are c;i ven s itaul tanco:>usly lu tile treatment or schizophrenic patients. SJ.nce it is not a compound, there is no spectophotometric curve. 2. 'l'iH~ nl•.:<YtlHu;•ticl o.nU. prl vine combinatl.on is ci ven lu ural •.:Uf.JSu.les in doses ol three rnilli<.:;!'G.;;Js or ;H·ivlnc aml .lull uilll[.;;re'l.ms cf nicotil}OJ:lirl. t·wice Q UO.;)'. 'l'he effect or t;d.G dOS:J.Ge is Geeu uver a i.'eriod or' •..:.o.ys; there is no sciz'..u·e, rather (...;radl~~-1 inprovement. The si1u(:!~ produced is n::li~ in the for!;; prod."L::;ed by !:lectrlc shock treatment. lt is in the form or a metabolic chane;e rather tha.n a loss of consciousness. 'l'llere is -; . no ~me:;ia, therefore. '.i.'~"e matabolic cht·nce iz manifested bJ ., CJ. louered bodJ· tem!Jeratnre, l'aleness, r;oos: bumps all over the body, a slauinr; or tile Inl.lse to n.pproximn.tely l~u, a .l::o'·leriug of tile blood presst~re to approximntely ')0 over rjo. c;iuce the p::.tieut..:; ;~re s<Jli7.ophrenlc, tile:;: uo nt)t rc;~.llzc the,y reel badlj' ;;.nd of teu t:o.l:~ arouncl in tills :;•Jmlition ';:ltilO'lL beillG a\r.J.re of discor.li'ort... One 1,1nt.Lent who 11ro.s occident;J.lly Given a. ·ll~Se uf t!le druc couoin:J. tion every hour for part of one d;:~~· did_ tell the nurse tilat he . ?referred other t~'Pcs of treat1nent. , . .• 3. There are no case hictorics on e:·:per ilJ;ent.rJ tLm '.ti tll nicot.inomid and privine since UL>ne \)f tne expc:-il:~ents llave oceu couple ted. Su r~r, ulllj• 12 patientz ho.ve been ci VCil thic treut- meut. claims that 20.to 100 cases would nave to 'be te:;ted t.Jeforc any r:aze hictories· c:oulU. be rele:;.sed even t;.J u cluced Gl'Oup. 'l'hls pro._!ected resear·~h l:·J.G rc·.:enLl~· been del~.;)C'l ll,Y baa we a. tiler, uilicn prevents the rloctors fro:-'1 truvellu•_; tu The document is a declassified CIA memorandum, evident from the "Office Memorandum" header and "UNITED STATES GOVERNMENT" text. It features handwritten annotations, including a series of letters and numbers in the top right corner, as well as marginalia that seem to be abbreviations or notes. The content is primarily text, formatted as a memorandum with fields for "TO," "FROM," "SUBJECT," and "Re." There are no photographs, diagrams, or evidence of experimental procedures visible in the document itself. The text discusses the use of drugs like nicotinomid and privine in treating schizophrenic patients, and the research's progress and any associated risks. 12 patientz ho.ve been ci VCil thic treut- meut. claims that 20.to 100 cases would nave to 'be te:;ted t.Jeforc any r:aze hictories· c:oulU. be rele:;.sed even t;.J u cluced Gl'Oup. 'l'hls pro._!ected resear·~h l:·J.G rc·.:enLl~· been del~.;)C'l ll,Y baa we a. tiler, uilicn prevents the rloctors fro:-'1 truvellu•_; tu tlle hospital, uut, l!lOl'e it:lportrl.nt than thls, Llle de::>.tll'u:r Olle of Lhe pat.leut:; '1-ihu ~T~!C 1u1der the nicu L.i.Uu!;liri uth1 pri vine t..re;• t: eut h~.r; mark it r:ecc::::cn.r:,- to :::lew tlL>Vn t.i1c e:·:peri; 1011 Ls 31J~,e~·Th:>. L even LilOU{.;h l.l•e ric;• Lh i.:::: m.:t uel icve·i to u~ •inc to Lhc d.r•1[; l!·c~·.t .. ;ent. LZ- <•er~. . r.lents Will ue renevcu ia the CIJrinc;. I h lte l::tr"Lr::.pil ;_· •)f ':.he suuje•..:L mc;,Ju, u;_a·. reciclellt o.c;ent '.lill cont.;;o.ct at tlle ,...._.. I . raa.inta.ininr; the some securit:,· classi.tico.tion on U:.il' s : t interest. l·leanwhile, OSI mD:i' be interested to know that the -------------is working with nicotinic a::ld, rather '~hem ulcotino;nid, o.nd the effect of this cl!'t~~ on psyciloses as Hell as 11sinG it i:1 t!1e treat;:~ent of pellac;!·a ;;ilLh rer.u.l.i..s frOiil C--o. clef.i.cienc;..• uf uicotinj_c o.cid.. or ti1e I I I.· ·, I ... ( -- - 2 - hn:z o.c: :: 'Jl'cHut:> to , L;:e o. t.ed 1 ~0 p:z:•chia.Lrlc p~.tleut.s uith uicot.iurc·· ~cirJ., usinG its blood - vessel dilo.t5.nG properties in her treo.tli!ent. These patients, CI!!pha.s:L7.ed, vere merely psychiat1·1c, not schlzoyhrenic.: awl not- confined. r· In cll:;cu.ssilJ.G ltls c:·:pe.L·imcntc -.,rl th nicotinoi.lid, c c.lso !uentionecl other CXfleri,::cntr> \·ihictl nay be of interest 1 to OS.i.. althout;h tiley do not; deal «ith ni•;utlnic a::ld oi.· nicotlnomid. c "13· repo-rts that the 1-ledical :.l•:hool - is studyiug the prolluction of epilepsy in patients by aw;tinisterinu setticarbazide in capsule fonn. 'l'his treatment has been used on si:< patients - three men and three vomen. The three men have de·.rel•:01'ed epllepr,y; the t.:1ree H01!1en have not bnt l!nve developed central vo1,1it.lnu; incte;.d. This see1us tons ·t.o uo.ve little to tlo 1ii til O~I 's ;m·.rent. iutereot but olucc there o.p~cared tiJ be C- sc~1e n.:;so...: iat i.:m for . we are sendinG it [).lon:.; in ;.;ase U:.il o.lso sees some com1ectioa. - I ~ ... fl . ·_,H " -. ·. .... ... -· I ... ..... - -........... . ~. •. .... · ......· -~--"f/1/1#'. -~· .. - ·. I ·'"··' .. , .. .... . Office Memorafzdtt1n This document is a typed page with handwritten marginalia and some obscured content. The marginalia, consisting of single letters like "Brc" and "C", are handwritten in black ink on the left side of the page. There are also several horizontal lines through parts of the text, indicating redactions, and some parts of the text are entirely blacked out. The content discusses experiments with nicotinic acid and nicotinomid, including the production of epilepsy in patients. A drawing that appears to be a crude sketch or symbol is located near the bottom right of the page. we are sendinG it [).lon:.; in ;.;ase U:.il o.lso sees some com1ectioa. - I ~ ... fl . ·_,H " -. ·. .... ... -· I ... ..... - -........... . ~. •. .... · ......· -~--"f/1/1#'. -~· .. - ·. I ·'"··' .. , .. .... . Office Memorafzdtt1n UNI1I'1ED STATES GOVERNMENT ,4 TO , CSI . . . . DATE: 13 February 1~52 Chief, Contact Division, 00 Fl. OM !- ..== · f/ SUBJECT: Case 1. Gh:1t:o:-man of +.h'3 L'cpartt'lent. of Bio- ~ chemistry and Dean of th'Ol GraC.uatP. Sc1Joo1, _ .• .c . was nontacted b\•+. ~ot1d acd l:i.t.tle t"o the informat-ion a.lread:r furnished • • i He referred the 00/0 representative to ----- Professor of . ·.1 I P~co1oeY in the J~dical School. c.. 2. r~oviccd the enclosed reprint of an ?Iticle which IJ a~·pP.ared in the AUGUSt 1'745 i~'Sue of +.he l~dical Jc,lrnal on the use of nicotj:~'lic acid in the treat1~1ent of rheum.J.t,oid art!lrit~s. This is the extent of his research vdJ,h th'3 acid. He: in turn referred c our man to , also of the t!edic~J. School faculty. .. , wrc i'S Profe:;sor of Heuro-Psyehiat.ry, provided the en closed reprint. of an article written by --on the us'3 of the acici in tile treat.l!lent of certai!'l 1crressed states. -...- has continued to con ~ d·~ct research on this subje~t. at the.----. State Hospital but ---is now using suc-::in<~.t.e :J.cid rat.her thafl nicotinic acid beca.usP._, as ~ states, it. has substantially the same effect as th~ latter anc is more c.J.sily administered. ·-pro'1lised to give t.•s re!'orts of two additional stuc.;ies on the sam subject, and these will be: forwarded when received. - -- .. ~ ~ 1 t Encl. - Two rAprints as described above i. '' : ·,- ~· .. The page is a "Standard Form No. 64, Office Memorandum" from the United States Government, dated February 13, 1952. It is primarily text-based, with typed content detailing research contacts and enclosed articles related to the use of nicotinic acid and succinate acid in treatment. Handwritten marginalia includes the notation "P/B, I, 27,6" at the top and a large "A" with scribbled lines below the main text. There are no photographs, diagrams, tables, or visual evidence of experimental procedures. Redactions are not apparent, and there are no official stamps visible.