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This document outlines a study's purpose to investigate the effects of drug extracts on thought controls and volitional activities, aiming to determine if suppressed information can be elicited and to identify signs and symptoms of drug effects.

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.. 4. Subject o! in~rcstigo.tio_n: a. Purposo or studr: Oui- princi;laJ. (:Oal re::ains the sa.."T".e as it iras in the beeL"l:rl..ng: the .in...-~s!.ig~~io: or drug e!ract.s 0:1 e!l:o controls ard '\-olitiona.l. activities, i.e., can \til.ful.~·- s~--· pressed inf'or~tio!'l "be elicited t!".ro:.:.gh tho aid of dr..lgs ~fcc tin~ b.ig.~er ;s:-\""C".!S centers? I! so, ~:hich age:tts are better f'or this pu..'"?ose? !,.;r.a:t: are t~e i.'"litia~ signs r:nd sympto:IS or drug errect:.;? Can these be recognized C"J' the subject o:- ocsel~ers? • I We ncrrr 2. . dd to these the rollou!ng: Can these signs ~r.d sj'T.!pto~s be tauzht to security officers so that they can detect th~ use or such acents in tr.e~~elves or others? Practical pu..-poses o! this stt.::iy are to gai.,' mror7.a tion ;~ich will pe!':".:i t t:.s • to detect lihat. -nork or a sil:llsr n:!.ture :ay l::.e in progress in e::c:r.:; har.ds (to l:a judged in esc~pod or returned prisc::ors). In r.r'J judg;;:~nt this is les3 i.-:;or~::~ than ours~lves disco\·erir.g hO"tr to elicit 1d1 ~ul.l;; suppre~.scd infer::;;. tic:t frc:: wartime pri3oncrs. Both of these pu~cses arc to ~ ~d less urgent th~n obtain!-~i in!'orr~ation rihich u:i.l.l :ierve to g"".. m rd ir.dividuaJ.s llbo possess tcp-level ir.i'o:-.:..a:tion !rem ir:discretions cc.ust::d b7 tb.e use of cl.ru)';;s o! ·the type stu.died here. There is · ~ q'..lestion t."lat clrt!gs ue C!.lre~dy- O:l hand· {and ne-J or.es are being prcduced) ti1~t. can dcst.:t-cy it!~grity ar:-d. z::s.ke ir.discrc:et tt.e ;.;ost C..oper;.C.a'bJ.e ir..di\-icl:.lal. E:~~=:,le: a physicist l:itb. top-level irJ:'ol-r.:.:.tion could be cade careless liithout his ~!"':·:.~;le~ge; In practical t-3rr.:s a table o! si;i!'.S E'~:-~ s~:'l:pto:.:s arisi•n•~il .J r . r cr::. the use of olC. ani esp~cia.J.ly nrm c.lrues fer .the use c! secl.\I-i. ty officers be prepnred as i::..!'C':-:·.a tion is obtair.od. o:ruch is already kr:.et;n at-out t.he "star.f.arcin ~E;f'nts, littla or. not.hii"lg a"Cot!.t the r.~::aY Sue.~ ~~~o:-::~tion is hi~~J;r C.e:;il':.:~l~ fc'!' c=:-:ic-.:.:::; :-t::.cc.:-~. B~ckgrcund: General plan o! st~dy: (1) · P~ot Study: This is at present nearing cor:pletion. It f1a!'s consisted of a series o! e:·:perizi,ents e:::ploy1.ng an e~::per!:.:en~al design fc:::" study or the ei'.fec ts of dr..:.ss on cc!"!scious suppression of e;,:per.....::-.cnt.al cr :r:o~­ t.}1....reat secl·ats. Drugs used h:;.-:e inclu:ed pentot!:al sodit:.l'll, sc:lim:~ a:-::"jtal., 't~!1:o­ dr!n~, ethy~ al.cohol, zcopolo'..ir..=, r.orpjir:-:!_, r.·3thedrine 1 and ::.:ulti.ple cc.:;i:i..n~".;.ic:-:.S of those c1·.J.gs as ;.=ell :!.s hypnosis ( c .f. ser.d.-2.m:u.a.l report or Juna 19, 1951) • Sin:e t-his i:liti.al :"Cport, ~odific:!.ticns or. this techr.ic hav~ The image is a graphic that advertises "The Black Vault," an online database of declassified government documents. To the left, there is a detailed illustration of a bank vault door, complete with a dial and intricate mechanisms. The text explains that the specific document is from the MKULTRA/Mind Control Collection, comprising over 20,000 declassified CIA pages. It states that the entire collection is free to download and provides a URL for access. There are no photographs, handwritten notes, stamps, forms, tables, or diagrams visible on this page. The visual elements consist solely of the vault illustration and the informational text. The document is a typed report with handwritten annotations in the top right corner and along the top margin. The handwritten text, in a cursive script, appears to be a date, location, and some notes. There are no photographs, official stamps, forms, diagrams, or tables. There is no visual evidence of experimental procedures, equipment, or facilities; the page primarily consists of typed text discussing a study of drug effects. e;,:per.....::-.cnt.al cr :r:o~­ t.}1....reat secl·ats. Drugs used h:;.-:e inclu:ed pentot!:al sodit:.l'll, sc:lim:~ a:-::"jtal., 't~!1:o­ dr!n~, ethy~ al.cohol, zcopolo'..ir..=, r.orpjir:-:!_, r.·3thedrine 1 and ::.:ulti.ple cc.:;i:i..n~".;.ic:-:.S of those c1·.J.gs as ;.=ell :!.s hypnosis ( c .f. ser.d.-2.m:u.a.l report or Juna 19, 1951) • Sin:e t-his i:liti.al :"Cport, ~odific:!.ticns or. this techr.ic hav~ been utili~cd in study or ether c.r..-:::t r:~scaline subj:::-cts. '1hese i'~'"!C..i... .-. &s as l-lell as thc:.e _o£ ::arih~:-.a C!nd lysercic acid., en the abar.da for the re::;:a:i.r...der of the year, ~·Ii.l~ t-e cicscrib~~. in the OUJ..."!ual report. In this p:llot study the er:phasis h;.s been directed. pri.":\arily at tbe effects o£ the above clrucs on the overt 'te!':.:t·.-ior or t..~e subjects, s;ecl.fical:l;r 0:::1 t::..e c:.c:Llit;; oi' th~ subje:d.; to ret~in ne,~eri:::er.~l secrets" and r.:aint.:tin cc:1trol o"i' his volu:nt:trJ act.i vi tics. Tl:e procc:;.ure utilized hr..s been cu Uinc-d in t!>e .:tbc:-te- r.:e:nticncd p1·ocrc~S -reporl. ..-· In £:t::l!"!ercl., the result::;· of this part o! tha ir.·.-estir:;r~tio:t, 1-:ith "l.~e e::<:C!;? tic::. or ether, h.:!. vc ir.clica '!..f.d that within t.r.e li::d t..s o! the <:i.<ount.!i .;:;cl:..in~ tcrtd, .. . • • 4 a.- Contii:Ucd ·-.. . ~· intcllcctu~l furr-tiorur.g and volitional co~trol has not been ~~paired ~ufficicnt~ to brc<lk dc.-..:n the e:-pcri::lenta.l set procuccd by tt:e nsecrct11• Tnu:. the next step involves the cvQ.luaticn or the v=:rious drucs as to their d.i.ffercntial. a~.t~r:;.ticn of psychological functions essential. to the r::ainter..ance of wilful. control • .... (2) As a result o£ the ate•~ pilot studies, it sc~~s clear that the pr~ctical ar.d secU!'ity aspects of the i.Iwestigation are only to be a!"s.:cre:~ by cval:uation of t.'-le difrerar.tial effe:cts or various dr..tgs on p:::;ychologtcal .ft~ctio:u: basic· to ego cont.ro~ ar.d volitional su:::prcssicn. To this end, a syster.atic e";"al or uation L~e cff~ct of d:ug aients on the f~icti~~ nec~sS~J to the ~ainter~ncc o.f ego controls h:c.s ~een i!".stituted ar.d constitutes tho l:le:ct. step in the proposed continuation of t.,e study. 'lbis invol-.-es r.sces!crily an ::·duou::, stc;;··l::t-:::tep investi€_;ation o£ the c!i'ect.s of- progz-essi ve ru:O'!.:..'"l'ts of drug as ..-all as variation o! in terrcgatio:l prcce::i1.:.ra, in that drug effects co r.ot bear a cor.stant.lir.aar relation to the ~~c~t of dr~g gi>en~ 'lhe objF-ct of this phase c.r t.te ir~vestigation is to discover -t!!e best agent as uell as the opt~~.l doses (co~~L~ad n~th the mosc eifecti•e interrcbation pro cedure) to r.:cdif:< ....-olitional control. For e:·:M;ple, teo large a dose of: r:ascal.i&~e 'hill induce such relation to the ~~c~t of dr~g gi>en~ 'lhe objF-ct of this phase c.r t.te ir~vestigation is to discover -t!!e best agent as uell as the opt~~.l doses (co~~L~ad n~th the mosc eifecti•e interrcbation pro cedure) to r.:cdif:< ....-olitional control. For e:·:M;ple, teo large a dose of: r:ascal.i&~e 'hill induce such nttked a!'..x.iety and less of re.ality co::1tc.ct that i.nforr:-.<ltion can- ... ,__ .... _ . .. : r~.., ~ re 1J".a~ .,.... . ;r oo .. ~:!..n~""'. It is prcpo~ed tr.at tbis furttcr sta? ~~ the in•estigation vill be e~fected oo in the prccE:ci'.l..!"es to subsc(iuently"descrited. {ci' (c), i!".!ra). b. nature of control ,.;ork (ci' (c) ir.fra). c. Hethod of procGd u:e: The prospectus fer further l·:crl:: accordingly include::; syst;rr..atic surYcy, in the ligbt of e;.:pg:-ier.ce ~aincd fr~ the pilot c:(pcri:::cnts, of dl ug ei'.fects l!!lderlyir~g the su~~ression ~~chanism. These ir.clude: (1) activation of a~~~cty associat~d idth bcsi"c cc:l:"..i'licts as ~.;ell as that incuced by the experir:er:tal situation, (2) brc:1kd~m of ch<lracter cefc:nscs ior the handl:in3 of an:ci.ety, in particuJ.ar those related to intellectual i'u.ict.lcns, (3) 1.-:~r:.or-J distur"cance, (4) discrie:nt.aticm as to time, place ar.d p::rscn (p:zrtic1.l.l.Clrly in regard to the chc:.nge j_ni;,:.ccd by t.."-le 1 dl1lg i!'l th::l ir:Ci>iciuc:.l's c~p:c.c:ity for realistic idc:-",tificaticn of the 5..nter::rc;;:-. tion situ.::.tion), (5) la."i);U:tge ch<:m&es (alt.ei·:ltion of synbol-rcfcrei~ relatio~Jip). Experir::ental Design: I. Ba~clir..e evaluation of etbove functions by: (a) Physical ey~~~naticn (b) P s:.·chia tric il"l. tcr·:ir~·.: (c) P ~'cbc::::otric c:·~-:i::~ tic-n (l) Rorschc::..zh · ' (2) TI~!!r..a.tic l.!Jf.Crccption '!est {3) Projoctiv~ Dr~<r:i.r:;:;s ) .. (h) ~~~t~lt rcrccrtic~ (S) l.r,::;:;~t::cc &;n.:llJ'::iiS C~::cd. Cl! J,OOO ~:ork ~;:,r,;plc of inte:rv:i.c-rT .. .. . . 4 · c·. Cor.tir.u!:d ' j .. ~· I , II. J..d..-..inistrc.ticn of drug and repetition of e·taluative procedm·cs as ~1:-ove, plus the "e:-;>erir.:cntal secrctu technic. III. Pkcc't:o :::xpcri:::.onts and t..~e "Un.':olo;.ms Technic": ..\. place c-o session ,;ill l;o . · L~te1~osed in a seri~s of dreg sessior.s to control suggesti~c effects o£ e::q:ari::~nta.l prccedurc ~ to cst:..bl.i:;h ns cbjec.ti•·cly ar~ ~ottr.c.ly as ca possible the o't:-scrvatior.s oi the e:>~crir.ental te~. These wlll. :>. part of the st-.J.dy ~~here t..'le agents used are Ct?loyed as un.'mc;ms, "l!r.kr:c::n to or all r.:e~:ers t~e te~ encaced il'l evcl.l!ntion. PrcYiC1'.lS l\Ol'X i.l"l. this lat'Orator:r h::.s ~b.o;;n +.hat the •itU'.kno;ms tcchnic11 is absolutely csse..'ltial l·:hen s-..:.bj!:c~i·;e re~o:'~es are c!ca:tt liith. The invcsti~a.tor 's bi:.s !;:'.~t l::e r~:oo•:ed. iil t..,is ;:ay. Usi~t; the st...,.~e subject !or The page contains typed text that appears to be part of a research report or experimental protocol, detailing intellectual functioning, volitional control, and psychological effects of drugs. There are no photographs, diagrams, or forms visible. However, there are handwritten annotations in the top left corner, including "La Continued" and a circular mark that could be an initial or a stamp. Additionally, there are instances of small dots and smudges scattered throughout the page, characteristic of older document reproduction. A large, faint "C" is visible in the bottom right margin, possibly a stamp or annotation. used are Ct?loyed as un.'mc;ms, "l!r.kr:c::n to or all r.:e~:ers t~e te~ encaced il'l evcl.l!ntion. PrcYiC1'.lS l\Ol'X i.l"l. this lat'Orator:r h::.s ~b.o;;n +.hat the •itU'.kno;ms tcchnic11 is absolutely csse..'ltial l·:hen s-..:.bj!:c~i·;e re~o:'~es are c!ca:tt liith. The invcsti~a.tor 's bi:.s !;:'.~t l::e r~:oo•:ed. iil t..,is ;:ay. Usi~t; the st...,.~e subject !or as mc.nJ• ·different druts as is ~dic~ly feasible constitutes a co~trol on iraiviclual di:rfer:nces. Ill the light of pre-."ious e~eri.--:ents it is jl!dgc.C. t..~at pentothal scdiu:'!, IUtribl!Clr..a, scopolar..ine, ::;o:-pi.inc, ether, r.:escaline, an:i probably l.ysei7;iC acid C!l"ld its derivatives ;;lll be drugs of particular interest in this stage of the invcstig~tion • . Cor:1pleti.on of this ph.:ase of the study -,;ill prov::..c.e the :L"":i'cr=:.cticn needed to dra::; up a table of dr.!g si&ns ·a:-.d syr.=ptons - s-u.bjecti-.·e a!".d nc . jective - referred to in' the "l\lip'osc11 section abo·.-e. IV. A fourth 'Oh~sc o! t!:le r:-orl: ;;ill be concern~d i11 the f'J.ture, as i.'"l t~e past, ltith the n:mrolot;ical. effects of the agents stt.:.died, in t.'lis in st;mce under e;.:pcrii:cntal conditions. or 'll:e basic k:!:o-..:lcC.ge the effects of these drugs on psyc~oJ.ogica~ i\J.:lctictir.g uill then pcrr.it specific i.""'l!'ozi.ed h:,~ot~eses of the n..,;b.ich ez·ug for ;:hich p:u-pc~~:· natur~, ;hie~ s~c'.!ld then l:e criticcl.ly tested uncle:- 11i'ieldn cor~iticns, i.e., prisoners of i'a:•, ii'. possible, Federal prisoners., ii' possible, secl.1.rity of.ficc:-s, etcc, un~er threat con:!itions beyor-..i the scope of civilian expcrircentation. () The document is a typed page of text with handwritten annotations. A circled number "119" appears in the top right corner. There is a handwritten mark in the form of a small "c." next to "Continued" in the top left. Several small, scattered dots appear throughout the document, which may be ink speckles or part of the original document's condition. No photographs, stamps, forms, diagrams, tables, or redations are visible.

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