Doc 0000144864

The page displays an image of a vault door on the left, with a glowing blue light emanating from it. To the right of the vault image, prominent white text reads "THE BLACK VAULT" in a stylized font. Below this title, informational text in a smaller white font explains that the document was obtained from an online database of declassified government documents, specifically from the MKULTRA/Mind Control Collection, which contains over 20,000 pages declassified by the CIA. A yellow hyperlink pointing to "http://mkultra.theblackvault.com" is at the bottom, indicating where the collection can be accessed. The overall visual aesthetic suggests a theme of secrecy and access to confidential information. OBJECTIVES OF PROJECT (BLANK) Object of Instruction The object of the present project is to test the most effective methods of inhibiting the alarm reactions usually stimulated through the autonomic nervous system in a wide review under stress. The method of approach is to develop chemical blocking agents or drugs which can be administered at the proper time to prevent both cholinergic and adrenergic manifestations of the autonomic nervous system. When stressed, red blood cells are poured into the circulation from the spleen; the blood volume reduces itself from the skin and splanchnic bed to the skeletal muscles and, on the whole, the organism is better prepared for fight or flight. (Good for all humans) This splanchnic innervation and the adrenal medulla, which liberates epinephrine, are involved in both the sympathetic and parasympathetic divisions of the autonomic nervous system. The acetylcholine release therefore affects all the categories of fibers in the parasympathetic system and also all autonomic preganglionic nerves, whether sympathetic or parasympathetic, the splanchnic (preganglionic) fibers to the adrenal medulla, the "sympathetic" fibers to sweat glands and certain blood vessels, and the somatic motor nerves to skeletal muscles. Plan of Procedure It is obvious that to arrive at the objective of these investigations suitable facilities for clinical testing must be provided. It is understood that these will be available elsewhere, but that preliminary clinical screening will be performed by the principal investigator to determine the most effective combination of anti-cholinergic and anti-adrenergic compounds for inhibiting alarm responses. At present, the standard anti-cholinergic and anti-adrenergic drug preparations usually combine phenobarbital and belladonna with or without the addition of xanthine derivatives or cyclopyrrolate. Among the available preparations marketed by drug concerns, the following are to be listed: BELLADONNA -- The alkaloids of belladonna leaf. Phenobarbital BELLADONNA -- Phenobarbital 1/4 gr. (16 mg.) Hyoscine Hydrobromide 0.0072 mg. Atropine Sulfate 0.0002 mg. Hyoscine hydrobromide 0.1280 mg. BELLADONNA -- Phenobarbital The above are listed in BELLADONNA -- Extractum Belladonnae 1/4 gr. (15 mg.) Extract. Belladonnae 1/6 gr. (10 mg.) Hyoscyamine sulfate 0.1037 mg. Atropine sulfate 0.0194 mg. Hyoscine hydrobromide 0.0065 mg. Phenobarbital (1/4 gr.) 16.2 mg. It is planned to administer these ro=.i::l.3 Ca le iu:::. !CllEtn'! .t A~ ID BEU.!..OO:m.l - Le~ut.u .:)cai.:.:l l/4 gr. ~- (l5 cg.) Ext.:' act. BG lla.doT'.n• l/6 gr. (10 t1g.) DO!nU.TJ..l. ~OGcya:.i:l.c au.lta.ta 0.1037 %:18• Atropine suJ.ta.te 0.0194 mg. ~oscine l:t;d:robro::dd e 0.006,5 ~· Pb!tnoba.rbit.a.l (l/4 gr.) 16.2 .:g. It is planr.sd to ad::inist~r these preparatior..:s first, in ordar to get a ba.se lim to deten:dns hO'I\' fa:r beyond these presentls' a\""ail.a.bla m.ateri::.ls the researchers ~t go to produ.ce satisfacto::t")" results. Tbs Dethods that ""-'! rill use here to screen the ef.fecti.-eness or these co:::;>ow:id.s will be the control of blood pressure 1.':1 eypertensi...-e patie::1ts :in patients 1 under e.xciteunt, a."ld also the effect of these CC>Ci'ound3 on the pu-:tar S"lreatini! test. This test is perfcroed by placing the palr:1 of U'..a subjectrs hand on filter paper p:-eviously dipped in tannic acid and dried. Tr.e al:10"Jllt of the ~print left by the hand is a measure · o.r pal:la.r s~atin6. The best of these p.relilli.i.narj cocpound:J wilJ. be given the grade "lDii, ·an:l ne-,r experi- -" mental p:-epa:aticns will have their effectiveness expressed ~ric~ I . according to their relati~ effectiveness as cccpared to the best of theso COT:90ll.nds • The use ·o!' new cOl:lpounds, avallable either Ca:::lercially or synt.hesi:: by the investigator, 'Ifill fall into two groups: The fi:'st ewoup w:Ul be labeled "A."lti-~rtensive Agents." The second group will ba labeled "Anti-cholioergic Agents." - •. . . . ~ .. -L- •' =. a ~ cf ~=~ aalb a! aJJQ-Jc;z1M p:!:tt.hU.a~ ot t;.b, double or ~ c!erinti"B: o! FOll:.:.ol• J. ~r tlzM. c~ b.:.~ b!Jo::1 pre pa.~ ~ ~ chic! in~t:tig&tor. Oth:l':l. r'Jll be dJk1ned ~res ·l.e:.d..ing ~ CCZ!j)zniee, :ra.eh as ~cJ.jm1 wb..icll is! a .s;r2p~t.~ic agart c.a=lwtod bT Cll!A, a:id D~rgec01"%1i%lo aTa.i.labl& !rt:2. S&ndo-:. or J,aoQg t.':s anti-ehol.ir.:3rzic ~p:.rati~, eaas tbr 6-::::eth=;r ~ dorlntiTe2 prepued by t~ :prm:ipal in~tig:d~~ ltill. bC t.oatad al~ '111 th blocking agsrt'"" derued £c:1r pilocarpine and e:serin. The~ are an catgrc:rth ot anti-utb:z:atic t.harapeuU.C :lt!,~nt.a c!srlsed 'bj- tbe ~i~ in~stisator. l%1 addition, he~ cott:Dercia.l~ avz.llable trUpplies, such cc:=:zpc~ 'rb: objoct, as previou.=lj· steltcd, · is to !'iod the ~t e!"fectiv o prevent tm relsa.:Je u:ndelr stnss or t.he cbelldcal et!ectorfl which prodtlce / tbe alar.~ respoce in individtl.ills • .J .. Tba principal investigator 1dll conduct botll acute a.nd chronic: toxicity studiea on all co;:tpOunds sub:rdtted !"or cli:c.ica.l inY&stigatiop.·. ln addition to t.i.is, prelimina17 p~ological. studies on the The page is a typed document with some handwritten annotations. At the top right, there is a handwritten note in black ink which appears to be "(b)(3)" next to the number "121" and the word "OFFICEAS:". There are no photographs, diagrams, or stamps visible on the page. The content appears to be scientific or research-oriented, discussing the "USE OF ANTI-HYPERTENSIVE AND ANTI-CHOLINE COMPOUNDS FOR THE CONTROL OF STRESS REACTIONS." The document is a typed page with a header indicating it's page "-2-". It contains paragraphs describing the autonomic nervous system and a "Plan of Procedure" for clinical testing. Below the text are two structured data listings under the headings "BELLADONAL" and "BELBARB", detailing different pharmacological compounds and their dosages. There are no photographs, handwritten annotations, official stamps, forms, diagrams, or evidence of experimental procedures visible on this page. ~t e!"fectiv o prevent tm relsa.:Je u:ndelr stnss or t.he cbelldcal et!ectorfl which prodtlce / tbe alar.~ respoce in individtl.ills • .J .. Tba principal investigator 1dll conduct botll acute a.nd chronic: toxicity studiea on all co;:tpOunds sub:rdtted !"or cli:c.ica.l inY&stigatiop.·. ln addition to t.i.is, prelimina17 p~ological. studies on the relatin anti-hypertensive and anti-cho~~crgic ·e!tects o! these cocpcunds will be c.u-ried out. , .- ... : .· . . ~ ..... I~ ·0:!) •. USB C? A~iTItrP:.r!-FrZ;cR~;miS!cVt E o A t liD sr -.A=~.:ls'.sT I-cHOtll~ CO'..l?OtniDS i\..""rt ::-.E..l~J.'.~.o.;s Tbs tol..lo1:1:lg b-adgct u p:rcpoecd !w tt-.eae inTaatigati02:1.3: J.a:U.nistraticc, c.t!ice oTerhsad and tra?Bl •••••••••••••••••••••••••••• part-ti:a ••••••••••••••••••••••••••••• Laborator:r technician far pa.tholog-'...: toxicity, etc ••••••• 2,400.00 eecti~, cr.r~ic Clinical technician tar clinical laborat~ d~tarmination •••••••••••••• .),000.00 ••...•...• 3,000.00 s lS,ooo.oo J - Nove:c::ber lJ, 19$1 - . r .• .. .. .. . -; -· Trp1co.l Haterinlo to ~ Ev!'.!J.u."l.tffi in Project: - . .'\. l3e.ntbii:c Other sta.cd.a..""'i s;:rntb3t1c Atropines - B1str1m& - Venl.oid Apro~ine {c~.) Exper~!ltal c:~.ltld.s vill be tried olll.y arter evaluation or acute acd ~bron!c toxicity d.s.ta (a::d otb"r pe!"tioe!lt data) by the =:-esponsible ~~dical Off1c:~r on tbe project. • , .. ---·-------- - .• . 'I .· •. . . '"; -· The document is a typed page with handwritten annotations. It lists various pharmaceutical compounds, including "PUROBARB," "NEBUTAL AND BELLADONNA," and "DONNATAL," with their respective ingredients and amounts. There are no photographs, stamps, forms, diagrams, or tables. Several small, dark specks are scattered across the page, possibly ink blots or imperfections in the original document. A few handwritten annotations are visible, consisting of short phrases or symbols. No redactions obscure any content on this page. This document is a single page of typewritten text, likely from a report or research proposal. There are no photographs, diagrams, tables, stamps, or forms visible on the page. The text is a single block of paragraphs with some slight formatting and marginalia. There are a few handwritten marks, including a dash at the top and a checkmark-like symbol near the middle. There are also a few scattered dots throughout the page, which might be imperfections in the original document or the scanning process. The text itself describes a research project involving anti-hypertensive and anti-cholinergic agents, but there is no visual evidence of any experimental procedures or facilities. This image is a scanned document with typewritten text. It appears to be an excerpt from a report, as indicated by the page number "-5-" in the upper left and the heading "USE OF ANTIHYPERTENSIVE AND ANTI-CHOLINE COMPOUNDS FOR THE CONTROL OF STRESS REACTIONS." A budget breakdown is presented, listing various positions and their associated costs, totaling $15,000.00. Handwritten annotations are present in the upper right corner, with a circled numeral "121". The date "November 13, 1951" is typed at the bottom. There are no photographs, diagrams, forms, stamps, or evidence of experimental procedures visible. This document is a typed memo with some handwritten annotations. It lists "Typical materials to be Evaluated in Project," including "Atropine," "Syntropan," "Benthine," and "Other standard synthetic Atropines." Further down, it lists "Bistrica," "Veraloid," and "Apresaline (CIBA)." A handwritten checkmark is visible next to "Atropine." The text also mentions that "Experimental compounds will be tried only after evaluation of acute and chronic toxicity data...by the responsible Medical Officer on the project." A handwritten "c" is present near the bottom right of the page, possibly a notation or initial. No photographs, stamps, forms, diagrams, or structured data are visible.