Doc 0000144864

OJJfltCTOMS OI"P'ICC.,.,, /;/,/ (bl~~') .. , Objoct ot In~:ti~ticn Ths o-~~t ~ tM p:c~ent project i& to .t:im t~ xxst _etfcct.i'i'";' msthod ct i,nh.Uiiting t.b= al:a-s raa!ltiCllll at~lllated tbra1gh th!> &utcmcide ne~ sri~: i~ ~'Vid-.1w und~r atrecc. The =stbod crt appro=h 1a to de~e ehe:dc:a.l blocki::.g ac,-cnt.s or ~ 1rtu..cb ~ be ad;:;in3ztered at t~ proper ths to prowmt. both cholinergic: and e.drer~r~ :n.=nUa::t.atiO'Q.! a! the auton=i::: :osl"'"I'CW: 1173t-.sl• red blood csll:t are poo.1red into tm circulation !rca tl::a spleon; t.hG blooi / _redut..""ib-.. rtee itsclt rra:. the akin alld 8plcnclmic bod to th~ ·akelsta.l. ~ . dlla"tcj and, c::l the "'l'hols, ~ organi=.a is better p-.rsp.usd !or r_igh't ,er tlish't. • (Good:: nn lot GilJ:an) tt ThiS splanchnic irax:naticn a: the adrerW.. moda ll.&· which ·libcrat 3o ~~~:.i.i:~~:;.!:J;.7...:r-.-·-··-··-~ ~~~·;:.c·.:-··~.:.- •. ~;;:. ··r·- . . , ... -2-. .. in both ths eympa.t.C.etic and p3ra:s;r=pathetic divisior..:s or the autopoc1.c nervOW! s;r:s~. The acetylchol~ rele-c:.siS therefo:-e af.!ect.s al~ the c01tGgorieD o! !ibe~ at the para:5j:lpath::atir: :r,r::te:= and a.,U!o al . l a:J. . t oncaic pregaJl6licnic nervo~, whether 8y:rpzt.h:lt1c or para:rppat.hctic, the spl.anchnic (pn~anglicmic) !ibers to ths adrsc.al aec!ulla, the ·~«.thetic" .fiber3 t.o s'Y:'Cat · gla.."ld.:: a."ld certain blood ve:sssl=, azd the sc:::matic t1otor ner~s to skeletal ~cles. Plan of P:-oced':lre It is obvious that to arrive at the objective of these inva!ltiga- t.ior.s suitable facilities fo:- clinical ~stil::.E; l'lll!St 'be prov-l-ded. It is 1 U.."lclerstood t.~~t these lfill be av~llible else"rhsre, but that prelo~.,.;na.:r.y clinica..J. screenint; ldll be performed b-J the pri.."lcipal inves·.:.igatcr to determioa the moet effective cotibination .or anti-chol~~ergic ~~d anti- edrer.ergic COt!pOU..'I'lds for inhibiting ala..-.:1 respor~es. . At present.the standard anti-~c holinergic and anti-adrenergic drJg preparation:~ usually combine pheoobarbital. and belladonna -,nth or without 7 _..the addition o! xanthine derivatives o:- cycscy2:1ine. AJ:long t!-.e available proparatio~ marketed lTJ d.-ug concerns, the !oll~_ng ~ be listed: • BEU...IDO~ -- Tne alkaloids of belladonna lea! Phenobarbital BELBL"U3 ;:::::== Phenobarbital 1/4 gr. :· (l6 mg. ) f\yoscine HYd.robromide 0.0072 z::g. Atropine Sulfate u.u2Lu ~g. ~o.scy ru:li."ll! rt·drobro:::~ide 0.1280 t'l6• .. . "; -· -J- •. P0?.03.1.~.B ~ Phenobarbital The ob ro=.i::l.3 Ca le iu:::. !CllEtn'! .t A~ ID BEU.!..OO:m.l - Le~ut.u .:)cai.:.:l l/4 gr. ~- (l5 cg.) Ext.:' act. BG lla.doT'.n• l/6 gr. (10 t1g.) DO!nU.TJ..l. ~OGcya:.i:l.c au.lta.ta 0.1037 %:18• Atropine suJ.ta.te 0.0194 mg. ~oscine l:t;d:robro::dd e 0.006,5 ~· Pb!tnoba.rbit.a.l (l/4 gr.) 16.2 .:g. It is planr.sd to ad::inist~r these The page displays an image of a vault door on the left, with a glowing blue light emanating from it. To the right of the vault image, prominent white text reads "THE BLACK VAULT" in a stylized font. Below this title, informational text in a smaller white font explains that the document was obtained from an online database of declassified government documents, specifically from the MKULTRA/Mind Control Collection, which contains over 20,000 pages declassified by the CIA. A yellow hyperlink pointing to "http://mkultra.theblackvault.com" is at the bottom, indicating where the collection can be accessed. The overall visual aesthetic suggests a theme of secrecy and access to confidential information. The page is a typed document with some handwritten annotations. At the top right, there is a handwritten note in black ink which appears to be "(b)(3)" next to the number "121" and the word "OFFICEAS:". There are no photographs, diagrams, or stamps visible on the page. The content appears to be scientific or research-oriented, discussing the "USE OF ANTI-HYPERTENSIVE AND ANTI-CHOLINE COMPOUNDS FOR THE CONTROL OF STRESS REACTIONS." ro=.i::l.3 Ca le iu:::. !CllEtn'! .t A~ ID BEU.!..OO:m.l - Le~ut.u .:)cai.:.:l l/4 gr. ~- (l5 cg.) Ext.:' act. BG lla.doT'.n• l/6 gr. (10 t1g.) DO!nU.TJ..l. ~OGcya:.i:l.c au.lta.ta 0.1037 %:18• Atropine suJ.ta.te 0.0194 mg. ~oscine l:t;d:robro::dd e 0.006,5 ~· Pb!tnoba.rbit.a.l (l/4 gr.) 16.2 .:g. It is planr.sd to ad::inist~r these preparatior..:s first, in ordar to get a ba.se lim to deten:dns hO'I\' fa:r beyond these presentls' a\""ail.a.bla m.ateri::.ls the researchers ~t go to produ.ce satisfacto::t")" results. Tbs Dethods that ""-'! rill use here to screen the ef.fecti.-eness or these co:::;>ow:id.s will be the control of blood pressure 1.':1 eypertensi...-e patie::1ts :in patients 1 under e.xciteunt, a."ld also the effect of these CC>Ci'ound3 on the pu-:tar S"lreatini! test. This test is perfcroed by placing the palr:1 of U'..a subjectrs hand on filter paper p:-eviously dipped in tannic acid and dried. Tr.e al:10"Jllt of the ~print left by the hand is a measure · o.r pal:la.r s~atin6. The best of these p.relilli.i.narj cocpound:J wilJ. be given the grade "lDii, ·an:l ne-,r experi- -" mental p:-epa:aticns will have their effectiveness expressed ~ric~ I . according to their relati~ effectiveness as cccpared to the best of theso COT:90ll.nds • The use ·o!' new cOl:lpounds, avallable either Ca:::lercially or synt.hesi:: by the investigator, 'Ifill fall into two groups: The fi:'st ewoup w:Ul be labeled "A."lti-~rtensive Agents." The second group will ba labeled "Anti-cholioergic Agents." - •. . . . ~ .. -L- •' =. a ~ cf ~=~ aalb a! aJJQ-Jc;z1M p:!:tt.hU.a~ ot t;.b, double or ~ c!erinti"B: o! FOll:.:.ol• J. ~r tlzM. c~ b.:.~ b!Jo::1 pre pa.~ ~ ~ chic! in~t:tig&tor. Oth:l':l. r'Jll be dJk1ned ~res ·l.e:.d..ing ~ CCZ!j)zniee, :ra.eh as ~cJ.jm1 wb..icll is! a .s;r2p~t.~ic agart c.a=lwtod bT Cll!A, a:id D~rgec01"%1i%lo aTa.i.labl& !rt:2. S&ndo-:. or J,aoQg t.':s anti-ehol.ir.:3rzic ~p:.rati~, eaas tbr 6-::::eth=;r ~ dorlntiTe2 prepued by t~ :prm:ipal in~tig:d~~ ltill. bC t.oatad al~ '111 th blocking agsrt'"" derued £c:1r pilocarpine and e:serin. The~ are an catgrc:rth ot anti-utb:z:atic t.harapeuU.C :lt!,~nt.a c!srlsed 'bj- tbe ~i~ in~stisator. l%1 addition, he~ cott:Dercia.l~ avz.llable trUpplies, such cc:=:zpc~ 'rb: objoct, as previou.=lj· steltcd, · is to !'iod the ~t e!"fectiv o prevent tm relsa.:Je u:ndelr stnss or t.he cbelldcal et!ectorfl which prodtlce / tbe alar.~ respoce in individtl.ills • .J .. Tba principal investigator 1dll conduct botll acute a.nd chronic: toxicity studiea on all co;:tpOunds sub:rdtted !"or cli:c.ica.l inY&stigatiop.·. ln addition to t.i.is, prelimina17 p~ological. studies on the The document is a typed page with a header indicating it's page "-2-". It contains paragraphs describing the autonomic nervous system and a "Plan of Procedure" for clinical testing. Below the text are two structured data listings under the headings "BELLADONAL" and "BELBARB", detailing different pharmacological compounds and their dosages. There are no photographs, handwritten annotations, official stamps, forms, diagrams, or evidence of experimental procedures visible on this page. ~t e!"fectiv o prevent tm relsa.:Je u:ndelr stnss or t.he cbelldcal et!ectorfl which prodtlce / tbe alar.~ respoce in individtl.ills • .J .. Tba principal investigator 1dll conduct botll acute a.nd chronic: toxicity studiea on all co;:tpOunds sub:rdtted !"or cli:c.ica.l inY&stigatiop.·. ln addition to t.i.is, prelimina17 p~ological. studies on the relatin anti-hypertensive and anti-cho~~crgic ·e!tects o! these cocpcunds will be c.u-ried out. , .- ... : .· . . ~ ..... I~ ·0:!) •. USB C? A~iTItrP:.r!-FrZ;cR~;miS!cVt E o A t liD sr -.A=~.:ls'.sT I-cHOtll~ CO'..l?OtniDS i\..""rt ::-.E..l~J.'.~.o.;s Tbs tol..lo1:1:lg b-adgct u p:rcpoecd !w tt-.eae inTaatigati02:1.3: J.a:U.nistraticc, c.t!ice oTerhsad and tra?Bl •••••••••••••••••••••••••••• part-ti:a ••••••••••••••••••••••••••••• Laborator:r technician far pa.tholog-'...: toxicity, etc ••••••• 2,400.00 eecti~, cr.r~ic Clinical technician tar clinical laborat~ d~tarmination •••••••••••••• .),000.00 ••...•...• 3,000.00 s lS,ooo.oo J - Nove:c::ber lJ, 19$1 - . r .• .. .. .. . -; -· Trp1co.l Haterinlo to ~ Ev!'.!J.u."l.tffi in Project: - . .'\. l3e.ntbii:c Other sta.cd.a..""'i s;:rntb3t1c Atropines - B1str1m& - Venl.oid Apro~ine {c~.) Exper~!ltal c:~.ltld.s vill be tried olll.y arter evaluation or acute acd ~bron!c toxicity d.s.ta (a::d otb"r pe!"tioe!lt data) by the =:-esponsible ~~dical Off1c:~r on tbe project. • , .. ---·-------- - .• . 'I .· •. . . '"; -· The document is a typed page with handwritten annotations. It lists various pharmaceutical compounds, including "PUROBARB," "NEBUTAL AND BELLADONNA," and "DONNATAL," with their respective ingredients and amounts. There are no photographs, stamps, forms, diagrams, or tables. Several small, dark specks are scattered across the page, possibly ink blots or imperfections in the original document. A few handwritten annotations are visible, consisting of short phrases or symbols. No redactions obscure any content on this page. This document is a single page of typewritten text, likely from a report or research proposal. There are no photographs, diagrams, tables, stamps, or forms visible on the page. The text is a single block of paragraphs with some slight formatting and marginalia. There are a few handwritten marks, including a dash at the top and a checkmark-like symbol near the middle. There are also a few scattered dots throughout the page, which might be imperfections in the original document or the scanning process. The text itself describes a research project involving anti-hypertensive and anti-cholinergic agents, but there is no visual evidence of any experimental procedures or facilities. This image is a scanned document with typewritten text. It appears to be an excerpt from a report, as indicated by the page number "-5-" in the upper left and the heading "USE OF ANTIHYPERTENSIVE AND ANTI-CHOLINE COMPOUNDS FOR THE CONTROL OF STRESS REACTIONS." A budget breakdown is presented, listing various positions and their associated costs, totaling $15,000.00. Handwritten annotations are present in the upper right corner, with a circled numeral "121". The date "November 13, 1951" is typed at the bottom. There are no photographs, diagrams, forms, stamps, or evidence of experimental procedures visible. This document is a typed memo with some handwritten annotations. It lists "Typical materials to be Evaluated in Project," including "Atropine," "Syntropan," "Benthine," and "Other standard synthetic Atropines." Further down, it lists "Bistrica," "Veraloid," and "Apresaline (CIBA)." A handwritten checkmark is visible next to "Atropine." The text also mentions that "Experimental compounds will be tried only after evaluation of acute and chronic toxicity data...by the responsible Medical Officer on the project." A handwritten "c" is present near the bottom right of the page, possibly a notation or initial. No photographs, stamps, forms, diagrams, or structured data are visible.