Doc 0000146089

~----- \-~ /"~ no:.r'i'~·=~·::; ; ... : JD ~.-:- ·~ :c~ ~~ ;:-:;;,·~ . '------ 1.----- Jr:sTHUCT d. ::S.-Qfliccr tlc~h~nn!ion' ahnu1~1 he \J~t'd in the ''TO"• cc.hunn. Unc'rr"c:u:h cnn1n\:nt :l line ,hou:.tl,·. . ;r,l\-.·n e.cr,,,, $hcct end c:1ch C:'lm&ncnt nurnh;.::cd to r.orrr•.ilrlfHI with 1J..i;; u~tmhcr in thr. "'f()"• col~nu\. E:u:!. t')IT"H·cr ~~· ........ ~:~ l:ht&.d (rhtek mnr:C in>u•i•cicnt) before further routine. Thi• Rccoro.l ~ntl r..:,Jlltin~ ~hcct •l•oulu be returned to r!•cbtry. kO. FP.OM: o:.n: to- RCOM OFFI·:r.r.·::; NO. t111fl,tl.5 P£C(I'.'[:J , rO~WU':OCO '· . -,.. --- ' C-:-r./SI I;:; 9. - ·,..~ - -· ~l 10. - '- .-..... ("•') (/) 0 ~ II. : c1-'_:: ~ 12.. .- 13. .. . .. 14. ' ... 1~. -- . • .... ...,.,... ... ~~ ~~~ 51-9-- ... - .... - . -t!\:::'E" -· - REST~h:TED ~--. ~= ·. .. . · .. · . .. "> . /} f) . ··t~~~y ;. u t". -· ..... ~ .!.._,.-... .~~ _::- ' -:;::- -:;-...; :;. s--~ j· • __c .;,o/•' h'-•)o !/. D-Lyscrt:ic Acid Dic:.hyl.:.:r.idc (LSD-25~ · • • J . --- ··----------------- AlthouGh the effect-s of ercot have beein- -~~o-'<-.n- -~d- -e-:r....~ c--:-ienccd by 0 0 - - 0 -- -- ) ---manY cou."ltries .. c!oro tr.rou0h rcco:-ded_hi,ztory,___t;.l~e_par.~ll~ _C:.!?£1£.0un_<!-, _____ _ " 2 . ----- lyscreic acid, •ms not di3covcred ~"ltil 1934. The LSD effect on tho 3 mind_ •~s not obser-ved u:1 t.il 1943. LSD produces a wide r<mge of· 0 -·pharmacological, physiolo;;ical and psychophysioloc;ical rc~ctions in both --0----. l., 5, 6 man and anir..als • Soze of the more outst~"ldL"lg effects are the ~ental confusion, =. .. r helplessnes;S a."ld extrer:e anxiety \otbich are produced by oinute doses of 5, 7 this substance. Based upon these reactions, its potential use by. ene:!JY nations in offensive _psychological 'o!arfare and in. interrogation ·is considerable and it r~y beco~e one of their r.Dst ~portant psycho- chemical agents. To date there is no kno\..n antidote. - Great interest in ei8ot has been sho\ 0.:1 b"j the Soviet bloc countries. bue to lo·,.,- :potency of the ergot collected in East Gerr:.an rye fields, r:othes a."ld co-\..-orkers have U."'ldertaken the cultivation of selected strains of ergot a"ld the a:-tificial infection of both ~·e and 9 barley. 0 The ~ufacture of lysergic acid is controlled by SM~:oz Ltd. ----o-- 10 o! Sr~tzerla"ld to whc~ the patc~t was issued. This company until recently had a virtual The page displays a dark background with a stylized graphic of a vault door on the left. The title "THE BLACK VAULT" is prominently displayed in a white, stylized font with blue accents. To the right of the vault image, white text describes the origin of the document as being from "The Black Vault," an online database of declassified government documents, specifically mentioning the MKULTRA/Mind Control Collection. This collection is described as housing over 20,000 declassified pages from the Central Intelligence Agency (CIA). The text also provides a website address in yellow at the bottom: "http://mkultra.theblackvault.com." There are no photographs, handwritten annotations, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures present on this page. This document is a routing and record sheet, likely an internal CIA form, with a title that reads "ROUTING AND RECORD SHEET." It features a grid for tracking document movement, with columns for "TO," "ROOM NO.," "DATE RECEIVED," "DATE FORWARDED," "OFFICER'S INITIALS," and "COMMENTS." Handwritten entries populate these fields, including a date of "20 Mar 1975." The "COMMENTS" section contains handwritten text and symbols, including what appears to be a numbered annotation "③," and other marks that could be notations or approvals. Several boxes within the grid are marked with checkmarks or initials, indicating the document has passed through various hands. The form is marked "RESTRICTED" at the bottom, alongside "CONFIDENTIAL." There are also several black rectangular redactions obscuring specific handwritten text. r:othes a."ld co-\..-orkers have U."'ldertaken the cultivation of selected strains of ergot a"ld the a:-tificial infection of both ~·e and 9 barley. 0 The ~ufacture of lysergic acid is controlled by SM~:oz Ltd. ----o-- 10 o! Sr~tzerla"ld to whc~ the patc~t was issued. This company until recently had a virtual r:.onoFoly on the pu:-chase of ert;ot gro\o:n in the United States. In the United States considerable inte_;rest has been ... .. I I I ~! ' . . ...... • t ~; ; •. f •• ••• ··'' .. nrou:J cd in p:J:rr.hoclv~r.U.cal a cent. !i and part icuLJ. rly in ly::;c rgic acid for use in pjychiatric Admixture;; co:lt.linint; acid ho~pitals. lyscq~ic other than with barbiturate::; to sh"'rten the period of dicthyl:t:n.i.d~ apprchcn:;ic:£ have not been tried. The bio!;j"Tlthcsis of ap.r-.:~.rently acid has not been attempted in this d~.l..y. sergic diethyla~ne count~/ - _ ·; ' :: ) ') as far as we knoH. ·Probably the greatest difficulty L~ the effective exploitation .. . •":' of lysergic acid and-its derivatives i~ the difficulty in extrapolating ---------------·--------- ---..... _. . --·-.. -11 e-xp-er-im-e-nt-al"-an-imal data back to hu=ans L~ o~der to pred_ic t re-s-u-lt-s. ........ --·····-.. -:-··--·"""'"':""---·· --··-----····.- .. --·-· ·- ........... _ Although so:::.e of the research uorkers are la1o;.,n to be reluctant to use this compo~~d !or clinical research, so~e research on the r.aterial has 12-14 been clinically evaluated a.~d recorded both in Boston and New York. SUH~f.ARY 1. D-Lysergic Acid is a agent of Diethylar~de psychoche~cal considerabl~ potential value as a strategic agent • . 2. The So\~et Union has sho~~ great interest in it and has proc~ed considerable of it. qu~~tities 3. The Sri.J'-:OCZ Ltd of Sid.tzerland is the r.ajor_ I:Ja.n\l.facturer of this substance. 4. Research on psychological studies this agent is going on in ~~th this co~~try. 5. The. synthesis of· this is long and difficult, and 15 stages co~poW'ld occur in the organic synthesis. The yield.of this.rnaterial is lmoim to be very lo\·t 'r;'hen obtained throuj'l partial synthesis fro::~ ergot.. . .. - !- .• .. ·. .... • ,..~;::, .• ·,I ·. 6. Uo Lio.::;:rnthc~i3 i3 bcinc undcrt~ken in t.hi:; country. 7. Sor..c clinical d.:l.ta arc avaihbi'c on it3 u.::;e both in thi::; country nnd in Europe. . . .· ... ·. ·o: .· .• -· , 3- ·. '• .. . '·. . . ... :~ · ~: · . ' ' Selected Lio.::;:rnthc~i3 i3 bcinc undcrt~ken in t.hi:; country. 7. Sor..c clinical d.:l.ta arc avaihbi'c on it3 u.::;e both in thi::; country nnd in Europe. . . .· ... ·. ·o: .· .• -· , 3- ·. '• .. . '·. . . ... :~ · ~: · . ' ' Selected V3 D H~ fr.:r-:-nr. ~!; 1. Burger, Alfred, i·:edi c irl."ll Chc::rl.!: t. :-•r, Vol. I, pp. 350, 19 51. , 2. Jacobs, ~·1. A. & L. C • .Craig, Jcurn:1l of !lio1.. Che!':l., Vol. 104,, . 'PP• 5h7- (1934) Stoll, 'ii. A., Schl:ciz. Arch. f. Neurol. u. Ps':"~!:iat., pp. 60, 279- (1947) Sa."ldoz Ltd., ?..cnort fro::1 the Phnr::-.acolor..v Latcratories, iio·:ember, 1952 5. Condrau, ·a., 11Clil"'..ical Experiences ,.n.th Lysergic Acid-r:..et.:--.7lamiC.e in Norrral a."lc! Eentally Sick Pe:-s9ns.11 Act<l Pz·:c:Oiat. c:. ,.:;'..lrol., Vol. 24, pp. 9-32, 1949 6. Forrer, G. R. & Gol=.ner, R·. D. 11E...">Cperir:.e:1.t Physiological S~t!dies with Lyser~ic Acid Diethylc>.=.iC.c (LSD)-25)11 .~.rc~. of ;:e~·-c:or;;r c_::=. Psvchiatrv, pp. 65, 5Sl-583. 1951 · 7. Savaee, Charles. 11Lyzergic Acid Diethyla::-.icie (!..SD-25), .!. :linic:.:..: Psycholodcal Stu::-r" A.-::erica."l Jou:-nal Psyc:Uat::r, Vol. :..:·2, pp. 276, 1952. S. \·1. l{a:;•er-Gross, EcAda:7'1: ~·!., ~·:alker, J. i·l. l1ATV?.E, Lcndc:;, '.~ol. lc3, pp. S27-62S. 1951 11Psychclc3ical & Bioche.:r.i.cal. .::::fects c: Lyse:-~:..c Acid Dictb:rl.a.-::ic!e. n "Cultive.tion 10. Patent Specificatio~ 579,484. App1. Date (U.K.) April 1944. Granted August 6, 1946 •. 11. Becker, A. g. "The Psychcpa.thology of the Lyse:-[:i.c AciC. r::..ethyl:..":i::.e Efi'ect.11 ~lien. Z. r!erYen::k. Vol. II,· pp. 1-54. 1949. ID. 740993 12. Rin~el, 1-!., DeS::.on, H. J., Hyde, R • ...l . ~ Solc:-:-.c~, H. C. n::_..;=?erir.:e::ta~ Schizophrenia-Like S:tr.:ptor:.s. 11 A::-.erica.n J O'..::r.-:.:.1 of Ps·rc::::..~,: !""T, Vel. 108, PP• 572-578? 1952. 13. DeShon, H. J., Rin}:cl, 1·:., & Solon6n, H. C.: "!·:c:1ta1 C::.an~es .Experi:nent.:UJ...v ?reduced by LyscrE:;ic Acid Dieth:;la.::lide.11 T:-:e .Psvchb.tric ~~«arte:-l·r, Vol. 26, pp. JJ-53, 1952. r .. . . .. • • l ~~·.:·.'· ' .... . .- 14. Ho:h, P. H., C~ttcll, J, P., & Pcnnc:J, H. H.: 11Effcct:J of J.:c:JcnHnc end L:,·::cr;;ic :.c~d" J'.::-.-:::-i~-:--'1 ;::lu:-:l.J.l or P:;·;c::i::.tr·r, Vol. lCZ, pp.5~?- 58h, 1952 • ... •. --·· ..... . . .· -2- ~· .. ..,._,__~ .~:::=::.t1i.~ APPfliDIX B .. Life C·rclc of Errot a. Head of r;c with pro~ncnt hardened, dark-red r~~gUJ bodies - ergot b. Sprout:ing ergot \<d.th several stalked globula:- heads ... c. Flask-shaped cavities in the surface of a single head i~edded d. Single caVity l-d.th nu:-.erous tube-like sexual sacs or asci e. Filifor.n The page contains typed text and handwriting. The typewritten text discusses the chemical compound D-Lysergic Acid Diethylamide (LSD-25) and its effects. There are several handwritten annotations scattered throughout the document, including a sequence of numbers and what appears to be a date. There are also numerical markings in the margins, possibly referencing other documents or sections. There is no visual evidence of experimental procedures, equipment, facilities, or photographs of people or locations. The document is a typed page with some handwritten annotations. There are several ink marks and smudges throughout the document, suggesting it may have been handled extensively. In the lower right corner of the page, there is a small, smudged postage stamp-like marking with a number within it. There is also a handwritten number "2" with a horizontal line above and below it, located near the center of the bottom of the page. The rest of the page consists of typed text, with the exception of some underlined portions and a scribbled-out section of text. There is a stamp with the text "-2-" inside a rectangular box. B .. Life C·rclc of Errot a. Head of r;c with pro~ncnt hardened, dark-red r~~gUJ bodies - ergot b. Sprout:ing ergot \<d.th several stalked globula:- heads ... c. Flask-shaped cavities in the surface of a single head i~edded d. Single caVity l-d.th nu:-.erous tube-like sexual sacs or asci e. Filifor.n ascspores in closed ~~d ope~ed sacs f. S:L~gle ascspores J capable of i.!'lfect:L~g rye flo•:ers, 1'orr..i::1g a myceli~~ there:L~ g •. Hyceliu.~, spreading in the g:-ain tissue, forr.=.ng bead-like, asexual spores (conidia) for further'infecticns .· 1 .. ~~ ~- ~-=-l!'· .. . • .. . . • t '· .;:,· •• '. •' The image is a scanned black and white document with significant noise and scattered ink spots. It contains typed text formatted as a numbered list, with items 6 and 7 present. Item 7 is further indented and continued on a second line. There is also a handwritten annotation "-3-" near the bottom, with a scribbled, enclosed shape below it. No photos, diagrams, stamps, or redactions are visible on this page. The image displays a page of text, formatted as a list of references titled "APPENDIX A." There are no photographs, stamps, forms, diagrams, tables, or redactions visible on the page. The text appears to be a bibliography, with numbered entries listing scientific articles and publications related to Lysergic Acid Diethylamide (LSD). There are no handwritten annotations or any visual evidence of experimental procedures. This page appears to be a bibliography or reference list, with item number 14 detailing a publication. There are no photographs, handwritten annotations, official stamps, or forms visible. Additionally, there are no diagrams, schematics, organizational charts, tables, or structured data. The page is primarily text, citing a research paper titled "Effects of Mescaline and Lysergic Acid" published in the American Journal of Psychiatry in 1952. There is also a page number or section indicator "-2-" present in the lower middle of the page, enclosed in a rectangle, and some smudged text or markings to the right of it. This document page contains text from an "APPENDIX B" titled "Life Cycle of Ergot." The text is formatted as a list with bullet points labeled 'a' through 'g', describing various stages of ergot. There are no photographs, stamps, forms, tables, or diagrams visible. There are some small, dark smudges scattered across the page, consistent with the age and condition of the paper, but they do not obscure any significant content.