Doc 0000148379

·- / u· .£, r~-I ~..,... . 7 , ! ' 15 January 1952 --------- j..-l HEHJRANDUN FOR: ~-~~-:--·,:~~~~.-.:..::~~._.;.:.~.e;(:.-·.:..:...~...:· .• :·~·:r":··=~~-~ SUBJECT Use of a Chemical Compound A 1. A bout a month ago, asked me i.f He' coUld giv~· him . aey 1...-lformation on nicotinic acid. He have made a number of discreet inquiries and have turned up i~orrnation as noted her~in. This in formation comes from one of the most promL~ent pharmacologists in th~ United States. We are makint; further inquiries of sources recorr.r:lended ty the individu<~.l Hho provided this i:uorma tion. One Gource in par ticular is reported to be doin:; research in nicotinic acid and \.;e may obtain even more ·useful information. I. 2. The informat~on pro\ined is as foll~~s: l The coMIT!on use ·of nicotinic acid ::i.s as a Yitar.tin; it is useci principally as a prevc:1tative for pe:p.::gra (a skin a.ffection.\lith se;:ere constitutional and nerv9us Sj'~tons) i."1 ·.:the southern oart of the US. Its therapeutic action in these cases 1~ in dcvelopinci a psychosis and dilating the blood vessels. Since ::.icot:i.'Lic cocid is a peri!"Jhe:-;;>l dilatot of blood ve~selsJ it :-d.cht, also r.e used i.'! thP. treatment of frost bite but there is no published :i.'1nication· that this t~-pe of therco.p:r h;;.s ·eYer been developed e.n;l1·ihere. . .... - His staff has don= much ·,rork on usine a combination of nicotinomid with orivine for the treatment of schizoohrenic patients. Pri·ii..~~ is a nicotinic a~id inhib.tor ( 3 h5) and, <Jlthough very lethal 1.."1 eni..-nalsJ i~ not poisonous for human hcinP.:::>. The nicotinomid-'.l .lrivine c0mbin;1t.iC'!1 produces <' sh')ck rea~ ction Hh ich dc~Js not :imrol Ye convulsions. ::x- -:Jeri;·,~nts i."1. this ha•:e been :rn~de on natients .:t t a. f) \ · · nearby tut are no lon~er beh1!5. '"::>-rried _on ce:::at.:.3e of the lo.ck of funds <tnd the difficulty in travel bet.reen L3 the, laboratories,, anrl. the hospital. TI1e source did not k:-1~~ of oth~r doctors or laboratories in the U'3 or abroad -.,;ho 1.;crP. t-torkine wi t.h thi~ nicoti..'1onid privi."'1e combimtion or other nicotinic :tcid c~ounds. He could not recall ha.Ying seen ar~r puclications on th.is s-.J.tject: - This image depicts a stylized graphic that serves as a title page or introductory screen for "The Black Vault," an online database of declassified government documents. To the left, a metallic vault door with intricate spinning wheels and a locking mechanism is shown, rendered in shades of gray and blue, suggesting security and the retrieval of sensitive information. To the right, white text on a black background announces "THE BLACK VAULT" in a stylized, energetic font, followed by descriptive text detailing the contents of the database, specifically mentioning MKULTRA/Mind Control Collection documents from the CIA. Notably, a web address is prominently displayed in yellow, indicating that the full collection is available for download and online access. There are no photographs of people, handwritten annotations, official stamps, forms, diagrams, tables, redactions, or visual evidence of experimental procedures. The document is a typed memorandum dated January 15, 1952, with the subject "Use of a Chemical Compound." It includes handwritten marginalia in the top right corner, reading "AIB. I, 64.21," and a circled "A" at the bottom. There are also a circled "B" and another circled "B" next to paragraphs labeled "B" and "B" respectively, which seem to denote sections or points. The text discusses nicotinic acid and its uses, including its therapeutic action in treating pellagra and its potential use for frostbite. It also details research combining nicotinomid with privine for treating schizophrenic patients, noting that experiments have been halted due to funding and logistical issues. No photographs, diagrams, stamps, forms, tables, or evidence of experimental procedures are visible. The content is entirely text-based, with the handwritten notations appearing to be indexing or filing marks.