Doc 0000148381

! ,(-:/:{~-~ P['/P 'f .. . .... ·- .. CENTRAL INTELLIGENCE AGENCY WASHINGTON ZS, D. C. ;";• ;l EE:-:c.R;uiDUii TC: D~puty Director/Plan::; '· SUBJECJ.' Trnn:::;mi ttnl of Scientific !ntelligence 1-:emor~-"lctun 1. Cur studies of unconventional wo.rfarc have included for some time the potential agent, Lys'3rt;ic Acid Dietllyl~.rtide (LSD), which appcr.r s to be better adapted thm1 knot-m druf_; s to both interro~;;ation of prisoners anU. usc a~ain:;t troops or civilians. The Soviet Bloc has tl1e necessary supplies of er(;ot from which to synthesize this d.r'tt;• Uoreover, the Eloc is presumably in full possJssion of the pertinent information on it si:1ce it is corrnnercially mrail~Lle a1r.. open lit ero. ture carries full e>ecounts, of e:---perincntal t:.3e. 2. !?-ec:.1u::;e ·...,e feel thnt tite matter m~jr be of conc~rn t,o :rou, we art! for\l~clinG th~ ::l.Lt::tcherl Sci~nti.fi.c Intelli::;o:1ncc L~worc:md.tDn, \.Jllici1 r5 bcu:::ccs briefl:r the intelli;_;cncc Liplicatio!l::; of LSD. C/~I hn.s in production c detn.iled ~tud7 on thi:; clrut; · that :ur.1r1~.rize::; the literature o:l t.he 5n:.,ject, rc::::.ounts the resv.lts of ncdic::tl ~:~eri!'1ento.tio~1 with it, and d~::lls t:ith it:.~_ possible s:rnthesi::; o.n-:1 production. Tl~is study, 11Gtrutc:.;ic ·' I:c~ical Si[;nific:.1nca of Ly::;crt;ic ilci:i Diethyl:-.:nide (LSD)", · will ::;oon be availo.bl~ to tbose who have a po.rn.-:10\.t!lt i.ntcre!it in the subject. A3:.:i~ Lan t Director :Jcicntiri c Int·~llicence ----- ~~z::r.~.~:...:.;.-7~·:---v: ::.-:·. ... -.,~:: :::-;;; ,:···:·~,.-~ ·: .. ~~~~~ ·:i ;·:~~~:\ ~··:& .. ~·:_:. .- -.:~ .~ ... :.:.:·::-<~:<~.:~~40:.'.~ ~~~-~ ~---~:.··:~'-!'1' :. .~ _~:;:;··=·~< . .. ~ .... _., -~ . .. ~----~=~:_ ~:·:: ·-:: ~::---;':':~. ·-·~.:· :~ .... -~~; ~::- ... .... .. . ·.CO~ . .# _;0 _, •. .:: .<-.·.·.,. . ·. ... · .•. ;- .. : .--_,. '. . . . ·. . -~ : I; • ':;• ._ • '· ~- SCIENTIFIC INTELLIGENCE MEMORANDUM ·. . . .·,. ,·. •·. . POTENTIAL NEW AGENT FOR UNCONVENTIONAL . WARFARE ! . ~· . . .. .. . . ;, · · ,._ ~'. · · lysergic Acid Diethylamide (LSD) ..· ': :_ :. · ~>,'_. (N, .N-Diethyllysergamide} .: • _t ·:::.~·-;>·, ..- :. :_-~: .':. (.)·\~:. . ~~~:.~;-:_·:"--.·.-·.·.·; .. ,• . . . .. . i: .. ·. ·. ' ~ . ... . :' .. \. - .. .. ·.· . ~ ,. "-: •. . . ~-~ . : •. . · .. . . . . ., . ,, .. ., ~ . . ... ' . . _ The page features a stylized graphic of a bank vault door with blue lighting, symbolizing security and hidden information. To the right of the vault, white text is superimposed on a black background, stating that the document originates from "The Black Vault," an online repository of declassified government records, specifically mentioning the MKULTRA/Mind Control Collection. The text further details that this collection contains over 20,000 declassified pages from the CIA and provides a web address for access. The overall design elements suggest a context of secrecy and the retrieval of sensitive, previously restricted information. There are no photographs, handwritten annotations, signatures, official stamps, forms, diagrams, tables, or visible evidence of experimental procedures on this page. . .. . i: .. ·. ·. ' ~ . ... . :' .. \. - .. .. ·.· . ~ ,. "-: •. . . ~-~ . : •. . · .. . . . . ., . ,, .. ., ~ . . ... ' . . _ CIA/51 101-54· I "I' , .. ·.·: . 5 August 1954 . • ,. . I , ~ •. .· , .: --· - .: .• •'' • J. ·, . -~- CENTRAL I N T E L L I G E N C.E AGENCY· ' : OFFICE OF SCIENTIFIC INTELLIGE_NCE ' . ... • ... ·a: . ':· 0: .". •_,. I . · ... -·.: . ·•·· ... .''. :' " .• ' . -~. ;· ' i. .... .. . .. • :, : ,•• I . :.- • '· •. '*'...,;.. -. •. .:.. ........ ' . ~·..,; ,._ .. -.- - . ·- ~~ .. ...- .,...__._ •' . ~ . .. ~ -- }'" ... \ J• I . I \..._.,' : Scientific Intelligence Memorandum '· POI'ENTIAL NEW AGENT FOR UNCONVENTIONAL WARFARE Lysergic Acid Diethylamide (LSD) (E, !-Diethyllysergamide) \ l - I ... I I ·...., I I I This memorandum is based on intelligence available as of 1 August 1954 . r CIA/SI 101-54 5 August 1954 C&"l"TRAL INTELLIGENCE AGENCY Office of Scientific Intelligeo~e 440A -· ... .. ·, ·.- ···:·"" . :-···'. 0 '· DISTRIBUTION Allen W. Dulles, OCI, 1 AD/SI,· 7 ... :- -11- . ........... .. . t ~ o :·--. .-... . .. • ·: ••· <4 , · ~ . ·, \ '-"'"! - -. ..__. - PCYI'EI·lTD\L lW AGENT FOR UNCONV"ENTIO!lAL wARFARE Lysergic ·Acid Diethylamide (LSD) (!,·!-Diethyllysergamide) Lysergic acid diethylamide (LSD) (N, N-diethyllysergamide), a drug·. derived from ergot, is of gr-eat strategic significance as a potential agent in unconventional warfare and in interrogations.* :In effe~ti~e doses, I..SD is· not lethal, no1· does it ~ave color, odor or taste. Since ·the effect of this drug is temporary in· contrast to the fatal nerve agents, ,there are important strategic advantages for its use in certain operations.. Possessing both a wide I!lal'gin of safety and the requisite physiological properties, it is capable of rendering •.rhole groups of :· people, including military forces, indifferent to their S\lr-rour..dings and situations, interferi!:lg witl'i planning and judgn:ent, and even creating apprehension, uncontrollable r.:or.fu&ion aod The document is a typed memorandum with handwritten annotations. At the top right, there is a handwritten inscription "PD/P/1870 8391". On the left side, a handwritten capital "A" is placed next to the salutation, and another similar "A" appears at the bottom. There are also two horizontal lines drawn across the page, one near the top and another near the bottom, that are not part of the typed text. No photographs, diagrams, tables, or specific experimental procedure details are visually present. This page is a declassified Scientific Intelligence Memorandum from the CIA, dated August 5, 1954. It features the title "POTENTIAL NEW AGENT FOR UNCONVENTIONAL WARFARE" and identifies the agent as "Lysergic Acid Diethylamide (LSD)". The document includes the official seal of the Central Intelligence Agency with the text "UNITED STATES OF AMERICA". There are no photographs, handwritten annotations, experimental procedures, or filled-in fields visible. The document also includes the classification markings "005" and "CIA/SI 101-54". advantages for its use in certain operations.. Possessing both a wide I!lal'gin of safety and the requisite physiological properties, it is capable of rendering •.rhole groups of :· people, including military forces, indifferent to their S\lr-rour..dings and situations, interferi!:lg witl'i planning and judgn:ent, and even creating apprehension, uncontrollable r.:or.fu&ion aod terror. pr all substances now knOH'tl to affect the mind, such as mescaline, • harmine a.OO~others, LSD is' by far tbe most potent. Very minutF; quantities (upwards of 30 millionths of a gram) create serious ment..a.l c·o~fus ion and t.~ .. sensual disturbances, or render the mind temporarily susc~t:ptiq_le to m.9ny types of' influences·.._ Administr·ation of the drug produces i.n an individual such mental characterist l~s· o1~ schizophrenla e.s visual or auditory hal!uci nations and physiological rea('tions ot' dizziness, nausea, d.ilatlon of the pupils, and ls.chryws.tion. The~e reactious, hm,..ever .• · s.r-e: not. nece.;;sat"ily obvious and only a trained observer, after giving f.:lY"'h·:.logic·al tests, may definitely ascertain t:Oat e. pnychogenic drug has Data, l'·~=rJ ·a~lJllniste-reli. although still very li.mited, are avallable which indir:a"te it..s usefulness for eliciting true and ... statemeut.s f'ro·m :;ubject::; uader tts influence a~~ta·at.e during interrogation .. It also revives of past e:x;per:!encE':s. In me.morie~ at least one ca.se the!'e wa!:> c·.omplete a.mnes.ia ot' eveots duc·ing the effective period. To date, no antldote nor specific cour:rters ge~t ia avallable. 'The efre·ct of LSD !riay, hm;ever, be .:;hor t.-:f~t":"d l.n duration !: y the 1JS~ cf t:hlcr;n.·oC!l.g,zioe, barbi:;ura7es, or the i~~rave:nons Jnjection of g1uco~e. Ve7 li.m:i.ted.zuc:thods of detect1.c:1 and ident~ric.3.t·Wtl ar-e kn~wn, su.::h as !luores~erJ~e, aT.aln~ng ! . h· and spectrcphctometry. Although the ~chan.l.sm of at~tlon.'or th:is .:.i'I:"'Ug. in the _>., human body is oct tully '.lnder::.tnod, H is nevertheless known to i.uterte:-e with the carbohyd·rate I!lP.ta·boH:;m arad to the r..'eJ:rl.::·al ')er·vcus oyste!ll., a..ffe~t. certain of the· 'brain· hc;rmones, and other body ft.m~tiO(JS. -i!QSI is nov comp.1et.ing a detai.led study cf I.Sl) that will dt=:al Y'i.th the composition of the. dr"t..lg, H ..: ; psychogenic _p::·opert1e:s ·' :. ts d.:·,relOl;tnerat, exper·i..Ir.er:rtal use, and distr ibut.ion. T:hts study enti t.l.ed "Strategi~ H~d ical ... I.· Significa!l ce of Lyserg1.r; Add D..i.et.hylE..!llide (LSD)" vill t;e ma.ae ~ v-a ils.b.le ~. ~ to those wi:;h a paramount inte.rest in the subject. -1- ·~-·-··· .· . . . .~ , ~ . . .. .. . - . · .. .. .. - . ~ . · . ••• -~ '!'~ . The document is a typed memorandum, dated August 5, 1954, from the Central Intelligence Agency's Office of Scientific Intelligence. The subject is "POTENTIAL NEW AGENT FOR UNCONVENTIONAL WARFARE," specifically identifying Lysergic Acid Diethylamide (LSD). There are no photographs, handwritten annotations, official stamps, forms, diagrams, tables, or redactions present on this page. The document appears to be a standard internal memo with its header, subject, and content in consistent, machine-printed text, suggesting it is purely informational. Add D..i.et.hylE..!llide (LSD)" vill t;e ma.ae ~ v-a ils.b.le ~. ~ to those wi:;h a paramount inte.rest in the subject. -1- ·~-·-··· .· . . . .~ , ~ . . .. .. . - . · .. .. .. - . ~ . · . ••• -~ '!'~ . . . ·~ - . •. - - • ~I ~ .• -~ ·,. ..... •· •- ·; ... - ...... ~ ... - ~ . / ·.,. - ____________ \..___., ---- ·.._ LSD is a partially synthesized drug and first prepared by Sandoz w~s Ltd., of Switzerland in 1943. The unusually complex synthesis_ of the lysergic acid fraction of the drug, attempted by many vorkers during the past 20 years, has apparently not yet been accomplished by any countrJ. Progress in the synthesis of_ the drug in the United States is reported to have reached the last and cost difficult stage. Completion of the syn thesis Yill facilitate the rapid Solution Of many problems, SUCh as that of an effective antidote, stability, more effective derivatives and/or ·combinations, more accurate dosage ranges, adequate methods of specific detection, dissemination and complete control, for: "'hich there are still strategic needs. urgen~ The material from vhich LSD is prepared is ergot and the Soviet ~asic Bloc has an abundant supply of it. The preparation.ofLSD has been pub lished openly in considerable detail. Further, Sandoz Ltd., r.as made available free samples of 1.t for clinical testing both in this colJutry and in Europe. It is therefore assumed that this material is available to the Bloc inasmuch as no ef·fective geographic limitation is k.nown. --.. 1 I ..: I. ' !'~ .. • ~. -2- Sf: /j;(~i & ··~ ./ ( --- ,. ~ . . and therefor>:> l.f3' cc·r, :Jf ethyl nlr:ol1ol z~l'.)l;L~ 'ue, !?.UC ] ec;,__ . " .. '0 rnnl~e a 50;'~ ~ol-:.rtion. T'hf.!'e is no need to •w:>rr:; oi;O'J.t: tho . s-necifi~ densit:... Afte>r dl1utJon the S1J.b::toncr. ~h-::mld l::e o.~1d n .22 ;zune:e needle 1> inr.h.os Lmr-. In.:; r.rt the nf!ed 1~ !} 1on;, the l.:m~ EL-:is of t!-:.P cir:nrette o.nd injPct zl•n;ly rneam:hi1e withdrawin( and rot~d:in,- the cir;-arette n'; +:h,... ~·l''r.f. time. ·, In;ir:oct :; of ~J1P GP~t~fd onount from on~ ~::H1 of' t.hf' r.i;G!'~·~tc .. I I I II; 1;. ·.::r:;t. to 'ut it in ~J~r roft or fatty .. . Ol' ~l-L.Jco1::~.te =.:Y"x.r..7..±ZE iceci'P!Jm. 'l'he ::nb~tnw·C" 1: :.:..·b~olu' This page appears to be a distribution list or routing slip from a declassified CIA document. It is predominantly text-based with no photographs, diagrams, or forms. There are some handwritten annotations, including a checkmark to the left of the "DISTRIBUTION" section. There are no official stamps visible, and no content is redacted. The text indicates distribution to "Allen W. Dulles, DCI, 1" and "AD/SI, 7," along with a page number "-11-" at the bottom. injPct zl•n;ly rneam:hi1e withdrawin( and rot~d:in,- the cir;-arette n'; +:h,... ~·l''r.f. time. ·, In;ir:oct :; of ~J1P GP~t~fd onount from on~ ~::H1 of' t.hf' r.i;G!'~·~tc .. I I I II; 1;. ·.::r:;t. to 'ut it in ~J~r roft or fatty .. . Ol' ~l-L.Jco1::~.te =.:Y"x.r..7..±ZE iceci'P!Jm. 'l'he ::nb~tnw·C" 1: :.:..·b~olu' •·1:.· or In c:Jch ci~·nrett.c .08 ccn tl:.•:> ~J1nt.i:)tt ·:.hich contnins .04 o•: the subst:anr.e. ~olution ~~lc~ contslns .01 ccs of the substnnce. If the I th~n ~vfry half t•J tr.l'E'e OtJ.':lrtr-:'rr-. o.': ~n hour b:.. - inl:'.aJnti.ot~ or ev~r:r t·~:o ::m<l ~ half t0 t.;!':reP. i~aurr ;):: i:1.··:'·;, tlon. '.Jl'. !'1U~ t -- S'J''"".c-A::;teo . i."' t.h0 ~ver~.:--n. It inholat!.on .nne.; i.n t.·;,·J ho~ws :i.f rl'.'Nl tJ:: nJt.J.th. . . ~ u.b .1 1!-: ct. 'T'}l:; t i::; : !l :ri1r:ld inUl\" ~,j11:tl r~.!~~: t;.r.·c_,J~~·.,~ ; .. ~,ral~.-~.f:'t.i _::~ '..;!1 fe.. . .. , r , '·. "•l.~ 'l'l'n: t· •... .·;-:'~"~'.r -_;., Ca.l.;.,._l",",',' ";'-"r", .1.. •,.•L.·lll'll.,.. ,.,.., ... · , ... ,.,,., ····t'\'C 'r·,.....,__,.l"l' y '· '· .;.; ... ~.· ~~ •• • ··- J. · ••.•• J:"l'"'- ... b r e :·: p e c t t-~ r: ·:; t t • '1 );..n·p ~~l~ .-(·-tr-•' \,I .... \. ; ~- • •· • • "· ;....I. e --------- --·------·-- -·--- ------~-·------ l. ,.., C..• 0. :~f'C'llrl-~- \J.~ ~~-t~,i:. tll '·~~- :::lrl rcrnorl: ·::if·.:·~ tl!'"; lntr.:::-P:,;-:n to:-. ~1. l.Jl,.iV!. . n·-:- rt,~cr:::lt:: t J til-~cn:;s p:~:;'=!lt')l ;~icnll:j c:·.arc:ecJ. -::·.:t; lt toplc~. ·J·;l:~tC·'J€1" itlLl'.i.~Ct;f'~l tr·;- in;~ to ;·:i t!1hold ·:.'ill 1Je i' or ere t~v tl:F top r.is. or' ~u:Jconsci.:>n::3 .,ind 8.lir.: t.Lc> n~c~r.::it:r to C.i:;cuss tl:lz Lopic lt ;)ne of t!1e M.Jzt . .1 , .. . A . . V c " .. l· l · .4 . . - t;. . L ' . - lp c ,. ,. , . . . . . .: . . . r . ~ ·. , ,; . ;- . 1 ~ .1 - . - . 1 or .1. t f l L · \ . . .. · . -·T •• . . _\ " 'te . - .... - i<,.," J · • ("1'11_ 1 . ' . _~ l~~t ·sentrnco is ;n.;,t ,t;o~cd. on ~·ciP.nt.j f'lc foct - ~ ·-·_;. .. . , . · . ~ ·. ... · . . ·-- ·-· . . - .. ........ ~. -. . - The image is a scanned page from a declassified document, presenting text-heavy content with no photographs, stamps, forms, diagrams, or tables. There are minimal handwritten annotations, including a red pen mark near the top and page number "-1-" at the bottom. The text itself is primarily typed, with some minor imperfections like smudges and slight variations in print quality. No redactions or visual evidence of experimental procedures are present. 'te . - .... - i<,.," J · • ("1'11_ 1 . ' . _~ l~~t ·sentrnco is ;n.;,t ,t;o~cd. on ~·ciP.nt.j f'lc foct - ~ ·-·_;. .. . , . · . ~ ·. ... · . . ·-- ·-· . . - .. ........ ~. -. . - '. . ~ - ,1 -, 5. Loquoci.:>·!:::A , .... ' - J r - . J ':~ ~: ~ ~ ,·:. ( I . ' ' I I (:). " • 1 ' G " l.. ..& .. . .,l \ ·r . • - ·~ '(\•.. . . . _ ., , l'lt- .. ' l lnc rn:.1 ;_· r:-·:..: of ::: ccJl: ---·---·· --- T'~" .• '· end n:. minor t·:>x.lc cffE!cts: A::; -:;i t.h oroer: c:d iu:- llst ' . tl:.e;:- f:Jllo·:; in ·Jrder of. occurrence. 3. .n.~ th~ni£J. 4 . IJ:!_[!_'(-:ult:r in rPr.:.,r:'..:r:rin=- P.vr-nt.c ;):11~; n f a . • . · . · s~c·J:l \ r]: .c ~·::-:. \.). 7. ·.. ... •:' :" t j_ · • ~ ~ : l: ~ ll ·· t ~ - t;! c [~ d c c.l I1 n r-=: • . "'- t· ) , ·' '· \! p (.\. ~::1:.1~lr., Lt-:ls1:L1,. G:1c.l ot:·,!"r '~"l:::-tr':l-intf!:~2r.r.l • C • : . ' .. , ' . ' . ' . ~ , ' , .. J . . • t,) ' J • · • l~ • ' · 0 · C ~ ~ • ... l ' i · , . .. . .. . · . ." " . , " . ... < ,, 1 , • I • . ~ ._ ll \ " , l'l \ r . ] p •. , " .. , - "'~T I i ! ' l' l " · 1· • . 0 . 1 , , ·. ~ o I • .. T t i~ 'JUt o:.: possiblr in 8 rPl~xed and infor~el so~lal settin~. I! the thf" ... · .•• • •· .:-!... .· • . •·· ·· . . • ~ -· .... ~ .....· .. ,. ..,·. . ~ . " . · . .... . . . .. . ... ................. .· ~ , · .. • - . ·· . .. . •._. ,.- - I, - fu t.u r P. • T~~P. 1 nte rr~r: B·:or : • f ~ .....· .. ,. ..,·. . ~ . " . · . .... . . . .. . ... ................. .· ~ , · .. • - . ·· . .. . •._. ,.- - I, - fu t.u r P. • T~~P. 1 nte rr~r: B·:or : • f • Jt l.~ rrocct:-dtn: ~l1[1~; :-~r: urH1F:r t>..: influence: of~ druc: •• Iiov;!•':~'>r, ., t dt<~ •.:) t~:-? t-:>.xlc ,...ffcet:2 ·:.rJtich rtf'~- or.:~:~_,, i. t-: t:- ··::r.ll t.) :·.~vc- .~,"'.VC: Ol'.·t. 1J1.._,.no:~_IJ1J!': J.rlJ""',,r,••q• ·.··',"t~C'.l t:t,~ i•1trr.,.''"''"')f·..._...., ,..'"'lll.: C''l_:,....,,ln <' •- - I" - J d r,· • • ' - .I J .J • - .I "•' :' '; t ..1. o~ In the .t:Jer-~1 cn~e thi~ ·::1.11 !lOt ...,C""" ... ..., ..... ,. "nr• L.l '"" ~."'"" ~ .~" J. ,• .\ inhr..lr.tlon .. I~. i.:- .:r·l':. ': ".'i~.n~:lr·i:}l~t thr ...I.I ' The page is a black and white, typed document with several faint ink smudges. There are no photographs, handwritten annotations, signatures, stamps, forms, diagrams, schematics, organizational charts, tables, structured data, or evidence of experimental procedures visible on this page. The text itself is the primary visual content, with the exception of a page number "-2-" at the bottom right corner. Content within the document appears to be slightly obscured by the texture of the paper and potential scanning artifacts, but there are no intentional redactions. The page is primarily text-based, with a handwritten annotation at the top right that appears to be a date, "11/9/16/21". To the left of this, there is a handwritten letter "B". There are no photographs, official stamps, forms with filled-in fields, diagrams, schematics, organizational charts, or tables. The text describes a substance and its dilution and injection into cigarettes, with mentions of syringes and needles, suggesting experimental procedures. There is a page number at the bottom right: "32-1". There are no visible redactions or obscured content within the main text. The image is a scanned document containing typed text. There are no photographs, handwritten annotations, signatures, official stamps, forms, diagrams, tables, or visual evidence of experimental procedures. The content appears to be a declassified report detailing drug effects and psychological observations related to interrogation. There are no visible redactions or obscured content on this page. The document is a typed page with handwritten annotations and some smudged ink. There are no photographs, stamps, forms, diagrams, or tables visible. Several lines of text have been underlined with blue ink, possibly indicating emphasis or notes. Additionally, there are handwritten notes in the margins and between typed lines, such as "The" and "M-r aciwity T" next to specific points, and some smudged illegible markings. Some areas of the document appear to be slightly obscured by smudges or dirt, but no formal redactions are present. This document page consists entirely of typewritten text, presented in several paragraphs. There are no photographs, handwritten annotations, signatures, stamps, forms, diagrams, charts, tables, or structured data visible. The text is generally clear and legible, with minor instances of slight fading or smudging. There are no visual representations of experimental procedures, equipment, or facilities depicted on this page.